Results 61 to 70 of about 6,251 (179)

Clinical Development of Therapies for Charcot–Marie–Tooth Disease: Recommendations for Trial Design, Endpoints, and Regulatory Pathways

Journal of the Peripheral Nervous System, Volume 31, Issue 3, September 2026.
ABSTRACT Charcot–Marie–Tooth disease (CMT) encompasses a heterogeneous group of inherited peripheral neuropathies. Despite being the most common genetic neurological condition, individual CMT subtypes are rare, presenting unique challenges for therapeutic development.
Charles K. Abrams, Sue Bruhn, Joshua Burns, Rebekah Fleming, Katherine Forsey, Vera Fridman, David N. Herrmann, Brian Lin, Susan McCune, Allison Moore, Susan Ruediger, Michael Shy, Shannon Strom, ToPIC:CMT Steering Committee, Shannon Strom, Peggy Allred, Dottie M. Caplan, Samuel Collins, David Goldstein, Christina Greeley, Benit S. Maru, Thomas Holm Pedersen, Terry Pirovolakis, Rachel Salzman, Iris Schultz   +24 more
wiley   +1 more source

A case-series study to explore the efficacy of foot orthoses in treating first metatarsophalangeal joint pain

Journal of Foot and Ankle Research, 2010
Background First metatarsophalangeal (MTP) joint pain is a common foot complaint which is often considered to be a consequence of altered mechanics. Foot orthoses are often prescribed to reduce 1st MTP joint pain with the aim of altering dorsiflexion at ...
Welsh Brian J, Redmond Anthony C, Chockalingam Nachiappan, Keenan Anne-Maree   +3 more
doaj   +1 more source

Switching From Intravenous to Subcutaneous Immunoglobulin Maintenance Treatment in Chronic Inflammatory Demyelinating Polyradiculoneuropathy

Journal of the Peripheral Nervous System, Volume 31, Issue 3, September 2026.
ABSTRACT Background and Aims Subcutaneous immunoglobulin (SCIg) is an alternative maintenance therapy to intravenous immunoglobulin (IVIg) in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). The CIDP guideline considers switching from IVIg to SCIg at an equivalent dosage reasonable; however, the optimal dosing strategy is unknown. This
Yelda Su, Pieter A. van Doorn, Bart C. Jacobs, Krista Kuitwaard   +3 more
wiley   +1 more source

Microfluidic Valve‐Integrated Garment for Smooth Sequential Gradient Mechanotherapy

Advanced Intelligent Systems, Volume 8, Issue 8, August 2026.
We present a soft wearable sleeve that delivers smooth, gap‐free compression using overlapping air‐filled actuators and tiny microfluidic valves. The system reduces bulk, lowers power needs, and uses a smartphone‐sized control box. It can provide sequential gradient compression, gradient pressure holding, and fast deflation, supporting more portable ...
Run Ze Gao, Chen Xi Huang, Drew M. Werbowski, Jacqueline Mary Kormylo, Clark R. Dickerson, Carolyn L. Ren   +5 more
wiley   +1 more source

Foot orthoses improve kinematic measurement in young women with biomechanical abnormality

Universa Medicina, 2015
BACKGROUND Foot pronation causes biomechanical abnormalities in the form of functional leg-length disparity. Foot orthoses are often used in the treatment of abnormal pronation. The aim of the study was to evaluate the effect of foot orthoses on abnormal
Maria Regina Rachmawati, Angela BM Tulaar, Muctarudin Mansyur, Ferial Hadipoetro Idris, Ismail Ismail, Ratna Darjanti Haryadi   +5 more
doaj   +1 more source

The Neuroprotective Potentials of Dual GIP/GLP1‐RA (Tirzepatide): From Preclinical Experiments to Clinical Trials: A Scoping Review

Brain and Behavior, Volume 16, Issue 8, August 2026.
The graphical abstract summarizes the current evidence on the potential neuroprotective effects of tirzepatide (TZP), a dual GIP/GLP‐1 receptor agonist, across mechanistic, preclinical, and clinical domains. Mechanistically, TZP is proposed to exert direct neural effects, preserve mitochondrial function, reduce apoptosis, oxidative stress, and ...
Yousef Hawas, Mohamed Abouzid, Ahmed Farid Gadelmawla, Dalia Kamal Ewis, Abdallah Khatatbeh, Yasmin Negida, Ahmed Negida   +6 more
wiley   +1 more source

3D Radiomic Texture Analysis of Quantitative Muscle MRI Enhances the Distinction Between Myotonic Dystrophy Type 1 and Charcot–Marie‐Tooth Neuropathy Type 1A: A Proof‐of‐Concept Study

European Journal of Neurology, Volume 33, Issue 8, August 2026.
In this proof‐of‐concept study, 3D radiomic texture analysis of quantitative muscle MRI (proton density fat fraction (PDFF, %) maps) distinguished the myogenic disease DM1 from the neurogenic disease CMT1A. Compared with DM1, CMT1A showed higher entropy, contrast, and lower homogeneity, reflecting a reticular vs.
Louise Iterbeke, Lotte Huysmans, Kobe Bamps, Ronald Peeters, Veerle Goosens, Frederik Maes, Patrick Dupont, Kristl G. Claeys   +7 more
wiley   +1 more source

Bamboo Medical Application: A State‐of‐the‐Art Review

Advanced Materials Technologies, Volume 11, Issue 14, 22 July 2026.
This review presents a structured classification of bamboo's current use in healthcare. It organizes applications into medical textiles and medical devices, with further divisions based on function and level of invasiveness. It also examines material utilization based on bamboo's structural role, highlighting how it supports both protective and ...
Haymanot Beza Lamesgin, Koosje van der Stoel, Vera Popovich, Paul Breedveld   +3 more
wiley   +1 more source

Compensatory Effects of Joint Bracing From a Kinetic Chain Perspective: Lower Limb Movement Coordination Analysis During Badminton Lunge Movements

European Journal of Sport Science, Volume 26, Issue 7, July 2026.
ABSTRACT This study investigated ankle, knee, and hip joint movement coordination during brace use via a lower‐limb kinematic chain approach, which may influence biomechanical factors associated with injury risk. Twenty badminton players performed a left forecourt kick lunge under four brace conditions. Kinematic and kinetic data were collected using a
Liwei Deng, Mengchao Cui, Yunqi Tang, Leichao Liang, Baichao Xu, Yuqiang Guo, Yong Wang   +6 more
wiley   +1 more source

Foot orthoses alter lower limb biomechanics but not jump performance in basketball players with and without flat feet

Journal of Foot and Ankle Research, 2019
Background Flat-footed individuals are believed to have poorer jump performance compared to normal-arched individuals. Foot orthoses are commonly used to support the deformed foot arch, and improve normal foot function.
Malia Ho, Pui Wah Kong, Lowell Jia-Yee Chong, Wing-Kai Lam   +3 more
doaj   +1 more source