Results 41 to 50 of about 141,308 (258)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
BMC Musculoskeletal DisordersBackground The patellofemoral joint (PFJ) stress as a primary mechanical stimulus in the patellofemoral pain (PFP) etiology is affected by plantar pressure symmetry.
Ali Yalfani +2 more
doaj +1 more source
Comparisons of Foot Pressure between Teenager Girls and Young Female Adults
Physical Activity and Health, 2018 Background: Increase age is one of the main factors influencing spatiotemporal and pressure parameters. Adolescence and young adulthood are unique periods in the life span that present opportunities and challenges in improving health.
Qianhui Fang
doaj +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
The relationships between foot arch volumes and dynamic plantar pressure during midstance of walking in preschool children. [PDF]
PLoS ONE, 2014 OBJECTIVES: The purpose of this study was to examine the correlation between the foot arch volume measured from static positions and the plantar pressure distribution during walking. METHODS: A total of 27 children, two to six years of age, were included
Hsun-Wen Chang +4 more
doaj +1 more source
Foot segments mobility and plantar pressure in the normal foot [PDF]
Journal of Foot and Ankle Research, 2014 Background The foot is generally regarded as a flexible structure which can adjust its flexibility in response to variable dynamic conditions in different phases within different motor tasks. In gait, both kinematics and baropodometry have shown to be affected by functional and structural factors [1].
Paolo Caravaggi +2 more
openaire +2 more sources
Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall +16 more
wiley +1 more source
The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp +4 more
wiley +1 more source
Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach +23 more
wiley +1 more source