Results 51 to 60 of about 2,711,818 (230)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Relationships between foot dimensions and plantar pressure distributed in older people

, 2020
The relationship between plantar pressure under the foot and the dimensions of the foot are essential for shoe manufacturers to design suitable footwear and evaluate foot problems, especially for older people.
Ali A. Al-Kharaz, Nibras S. Abbas, Hanan Al-Hadeethi, Al-Hadeethi, Hanan, Albert Chong, Chong, Albert, Abbas, Nibras S., Al-Kharaz, Ali A.   +7 more
core   +1 more source

Sarcopenia diagnosis using skeleton-based gait sequence and foot-pressure image datasets

Frontiers in Public Health
IntroductionSarcopenia is a common age-related disease, defined as a decrease in muscle strength and function owing to reduced skeletal muscle. One way to diagnose sarcopenia is through gait analysis and foot-pressure imaging.Motivation and research ...
Muhammad Tahir Naseem, Na-Hyun Kim, Haneol Seo, JaeMok Lee, Chul-Min Chung, Sunghoon Shin, Chan-Su Lee   +6 more
doaj   +1 more source

Characteristics of Ankle Strategy Responses to Dynamic Tilting Perturbations [PDF]

한국정밀공학회지, 2018
Maintaining balance is a factor critical and integral to our effective physical function as it relates to the normal activities of daily living. Of the “hip strategy”, “stepping strategy” and “ankle strategy”, it is known and accepted that the “ankle ...
Hansol Seo, Hohyun Jung, Dukyoung Jung, Dohyung Lim   +3 more
doaj   +1 more source

Plantar pressure distribution profile of type 2 diabetes mellitus with diabetic foot syndrome: A hospital-based observational study

Сахарный диабет, 2022
INTRODUCTION: The prevalence of diabetic foot syndrome is increasing in the Indian population. It is a triad of neurological, vascular, and biomechanical changes due to long term diabetes mellitus (DM).
H. Ya. Korada, E. Arora, Sh. K. Rao, M. Hande, S. Shetty, A. G. Maiya   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

CLINICAL EXAMINATION AND FOOT PRESSURE ANALYSIS OF DIABETIC FOOT: PROSPECTIVE ANALYTICAL STUDY IN INDIAN DIABETIC PATIENTS

National Journal of Medical Research, 2016
Aim: Clinical examination of diabetic foot to find out its pathological Complications and analysis of plantar foot pressure of diabetic foot patients in Indian population. Method: This was prospective analytical study in Indian diabetic patients. 102
Harshanand J Popalwar, Anil Kumar Gaur, Badrinath D Athani, Jayasree Ramesh   +3 more
doaj  

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Forefoot plantar pressures in rheumatoid arthritis [PDF]

, 2004
We sought to investigate the magnitude and duration of peak forefoot plantar pressures in rheumatoid arthritis. The spatial and temporal characteristics of forefoot plantar pressures were measured in 25 patients with a positive diagnosis of rheumatoid ...
Otter, Simon, Young, A.K., Bowen, C.J.
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