Results 51 to 60 of about 2,863,160 (274)

Protocol for the Foot in Juvenile Idiopathic Arthritis trial (FiJIA): a randomised controlled trial of an integrated foot care programme for foot problems in JIA [PDF]

, 2009
<b>Background</b>: Foot and ankle problems are a common but relatively neglected manifestation of juvenile idiopathic arthritis. Studies of medical and non-medical interventions have shown that clinical outcome measures can be improved ...
Sturrock, R.D., Hendry Gordon J, McColl, John, Sturrock Roger D, Lorgelly Paula K, Woodburn Jim, Woodburn, J., McColl John, Sturrock, Roger, Gardner-Medwin, J., Gardner-Medwin Janet, Turner, Deborah E., Browne, Michael, Turner, Deborah, Browne Michael, Hendry, Gordon, Lorgelly, Paula K., Hendry, Gordon J., Lorgelly, Paula, Sturrock, Roger D., Woodburn, James, Watt Gordon F, Gardner-Medwin, Janet, Hendry, Gordon; id_orcid, Browne, M., Turner Deborah E, Friel, L., Turner, D.E., Watt, Gordon, Friel, Lorraine, Hendry, G.J., Friel Lorraine, McColl, J., Lorgelly, P., Watt, G.F., Watt, Gordon F.   +35 more
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Design of 3D printed pressure-reducing insoles based on changes in parameters of lattice structure

Advances in Mechanical Engineering, 2023
Uneven distribution of pressure on the bottom of the foot or excessive local pressure shall cause discomfort. And when it gets severe, this pressure would even damage the health of the human foot, especially for people like the elderly, diabetic patients
Lu-Ping Kang, Tai-Sheng Gong
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Relationships between foot dimensions and plantar pressure distributed in older people

, 2020
The relationship between plantar pressure under the foot and the dimensions of the foot are essential for shoe manufacturers to design suitable footwear and evaluate foot problems, especially for older people.
Ali A. Al-Kharaz, Nibras S. Abbas, Hanan Al-Hadeethi, Al-Hadeethi, Hanan, Albert Chong, Chong, Albert, Abbas, Nibras S., Al-Kharaz, Ali A.   +7 more
core   +1 more source

Plantar pressure distribution profile of type 2 diabetes mellitus with diabetic foot syndrome: A hospital-based observational study

Сахарный диабет, 2022
INTRODUCTION: The prevalence of diabetic foot syndrome is increasing in the Indian population. It is a triad of neurological, vascular, and biomechanical changes due to long term diabetes mellitus (DM).
H. Ya. Korada, E. Arora, Sh. K. Rao, M. Hande, S. Shetty, A. G. Maiya   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

CLINICAL EXAMINATION AND FOOT PRESSURE ANALYSIS OF DIABETIC FOOT: PROSPECTIVE ANALYTICAL STUDY IN INDIAN DIABETIC PATIENTS

National Journal of Medical Research, 2016
Aim: Clinical examination of diabetic foot to find out its pathological Complications and analysis of plantar foot pressure of diabetic foot patients in Indian population. Method: This was prospective analytical study in Indian diabetic patients. 102
Harshanand J Popalwar, Anil Kumar Gaur, Badrinath D Athani, Jayasree Ramesh   +3 more
doaj  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source