Results 31 to 40 of about 144,067 (258)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Characteristics of Ankle Strategy Responses to Dynamic Tilting Perturbations [PDF]

한국정밀공학회지, 2018
Maintaining balance is a factor critical and integral to our effective physical function as it relates to the normal activities of daily living. Of the “hip strategy”, “stepping strategy” and “ankle strategy”, it is known and accepted that the “ankle ...
Hansol Seo, Hohyun Jung, Dukyoung Jung, Dohyung Lim   +3 more
doaj   +1 more source

Plantar pressure distribution profile of type 2 diabetes mellitus with diabetic foot syndrome: A hospital-based observational study

Сахарный диабет, 2022
INTRODUCTION: The prevalence of diabetic foot syndrome is increasing in the Indian population. It is a triad of neurological, vascular, and biomechanical changes due to long term diabetes mellitus (DM).
H. Ya. Korada, E. Arora, Sh. K. Rao, M. Hande, S. Shetty, A. G. Maiya   +5 more
doaj   +1 more source

Diabetic foot or pressure ulcer on the foot? [PDF]

, 2011
Diabetes is one of the greatest health challenges facing the United Kingdom (UK) today, with 2.5 million people diagnosed with diabetes in the UK, not including up to half a million people who have the condition but are unaware of it (Diabetes UK, 2009).
Ousey, Karen, Chadwick, Paul, Cook, Leanne   +2 more
openaire  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

CLINICAL EXAMINATION AND FOOT PRESSURE ANALYSIS OF DIABETIC FOOT: PROSPECTIVE ANALYTICAL STUDY IN INDIAN DIABETIC PATIENTS

National Journal of Medical Research, 2016
Aim: Clinical examination of diabetic foot to find out its pathological Complications and analysis of plantar foot pressure of diabetic foot patients in Indian population. Method: This was prospective analytical study in Indian diabetic patients. 102
Harshanand J Popalwar, Anil Kumar Gaur, Badrinath D Athani, Jayasree Ramesh   +3 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source