Results 81 to 90 of about 12,661 (221)

Nanozyme‐Reinforced miR‐197‐3p Delivery Resets Metabolic and Senescence Pathways to Rejuvenate Osteoarthritic Cartilage

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a progressive and disabling joint disease driven by oxidative stress, chondrocyte senescence and extracellular matrix (ECM) degradation, yet lacks effective disease‐modifying treatments. In this study, we identified miR‐197‐3p as a previously unrecognized, cartilage‐protective miRNA significantly downregulated in both ...
Xuejie Cai, Zehui Lv, Chen Zhang, Xingdong Yang, Ruoying Wang, Yixin Bian, Jiawei Xu, Han Wang, Yingjie Wang, Long Bai, Jiacan Su, Xisheng Weng   +11 more
wiley   +1 more source

The DECADE cosmic shear project III: validation of analysis pipeline using spatially inhomogeneous data

The Open Journal of Astrophysics
We present the pipeline for the cosmic shear analysis of the Dark Energy Camera All Data Everywhere (DECADE) weak lensing dataset: a catalog consisting of 107 million galaxies observed by the Dark Energy Camera (DECam) in the northern Galactic cap.
D. Anbajagane, C. Chang, N. Chicoine, L. F. Secco, C. Y. Tan, P. S. Ferguson, A. Drlica-Wagner, K. Herron, M. Adamow, R. A. Gruendl, M. R. Becker, R. Teixeira, Z. Zhang, A. Alarcon, D. Suson, A. N. Alsina, A. Amon, F. Andrade-Oliveira, J. Blazek, H. Camacho, J. A. Carballo-Bello, W. Cerny, Y. Choi, C. Doux, M. Gatti, D. Gruen, D. J. James, E. Krause, N. Kuropatkin, C. E. Martínez-Vázquez, P. Massana, S. Mau, J. McCullough, G. E. Medina, B. Mutlu-Pakdil, M. Navabi, N. E. D. Noël, A. B. Pace, A. Porredon, M. Raveri, A. H. Riley, J. D. Sakowska, S. Samuroff, D. Sanchez-Cid, D. J. Sand, L. Santana-Silva, M. Soares-Santos, G. S. Stringfellow, C. To, A. K. Vivas, M. Yamamoto, A. Zenteno, J. Zuntz   +52 more
doaj   +1 more source

Enhanced Antibacterial Properties of Lyotropic Liquid Crystalline Nanoparticles via Curvature Modulation

Advanced Science, EarlyView.
Lipid nanostructured particles with increasing negative Gaussian curvature progress from vesicles to P‐cubosomes and D‐cubosomes. This curvature hierarchy enhances interaction with bacterial membranes, promotes membrane remodeling and leakage, and potentiates daptomycin activity against MRSA.
Xiangfeng Lai, Shuhong Wang, Chenguang Ding, Xenia Kostoulias, Anton P. Le Brun, Hsien‐Yi Hsu, Jhih‐Hang Jiang, Yajun Wang, Richard A. Strugnell, Anton Y. Peleg, Hsin‐Hui Shen   +10 more
wiley   +1 more source

Photonics Breakthroughs 2025: Mask-Based Integrated Miniscope for Large-scale Volumetric Imaging

IEEE Photonics Journal
Mask-based integrated microscopy represents a powerful computational imaging paradigm, enabling 3D imaging over a large field of view within a thin device footprint.
Feng Tian, Weijian Yang
doaj   +1 more source

Systemic Nanomechanical Single‐Cell Profiling Reveals Mechanophenotype Transitions Under Therapeutic Perturbation

Advanced Science, EarlyView.
Single‐cell mechanomics demonstrates that pharmacological perturbation changes cytoskeletal and cortical structure, suppressing cancer cell invasiveness. By integrating atomic force microscopy (AFM)‐based cortical measurements with stimulated emission depletion (STED)‐resolved adhesion and cytoskeletal organization, this approach identifies nanoscale ...
Minhee Ku, Jinwon Kwon, Nara Yoon, Hyung Kwon Byeon, Jaemoon Yang   +4 more
wiley   +1 more source

An Artificially Selected Cytokinin‐Pathway Transcription Factor Balances Soybean Yield and Pathogen Resistance

Advanced Science, EarlyView.
A cytokinin pathway transcription factor, RR2b, was artificially selected during soybean domestication and improvement based on its differential transcriptional activity, which correlates with ATT repeat polymorphisms in its promoter. RR2b balances yield and defense by fine‐tuning its expression level and offers a promising target for decoupling trade ...
Qun Ma, Yaqing Chen, Yiwen Gao, Xueting Hu, Qun Yang, Yucheng Liu, Peiyong Xin, Jijun Yan, Jinfang Chu, Lei Li, Zhixi Tian, Bo Ren   +11 more
wiley   +1 more source

The DECADE cosmic shear project IV: cosmological constraints from 107 million galaxies across 5,400 deg$^2$ of the sky

The Open Journal of Astrophysics
We present cosmological constraints from the Dark Energy Camera All Data Everywhere (DECADE) cosmic shear analysis. This work uses shape measurements for 107 million galaxies measured through Dark Energy Camera (DECam) imaging of $5,\!412$ deg$^2$ of sky
D. Anbajagane, C. Chang, A. Drlica-Wagner, C. Y. Tan, M. Adamow, R. A. Gruendl, L. F. Secco, Z. Zhang, M. R. Becker, P. S. Ferguson, N. Chicoine, K. Herron, A. Alarcon, R. Teixeira, D. Suson, A. N. Alsina, A. Amon, F. Andrade-Oliveira, J. Blazek, C. R. Bom, H. Camacho, J. A. Carballo-Bello, A. Carnero Rosell, R. Cawthon, W. Cerny, A. Choi, Y. Choi, S. Dodelson, C. Doux, K. Eckert, J. Elvin-Poole, J. Esteves, M. Gatti, G. Giannini, W. G. Hartley, D. Gruen, K. Herner, E. M. Huff, D. J. James, M. Jarvis, E. Krause, N. Kuropatkin, C. E. Martínez-Vázquez, P. Massana, S. Mau, J. McCullough, G. E. Medina, B. Mutlu-Pakdil, J. Myles, M. Navabi, N. E. D. Noël, A. B. Pace, A. Porredon, J. Prat, M. Raveri, A. H. Riley, E. S. Rykoff, J. D. Sakowska, S. Samuroff, D. Sanchez-Cid, D. J. Sand, L. Santana-Silva, I. Sevilla-Noarbe, T. Shin, M. Soares-Santos, G. S. Stringfellow, C. To, A. Tong, M. A. Troxel, A. K. Vivas, M. Yamamoto, B. Yanny, B. Yin, Y. Zhang, J. Zuntz   +74 more
doaj   +1 more source

Bio‐Inspired Bidirectional Winding Origami With Programmable Modular Reconfigurability and Scalability

Advanced Science, EarlyView.
A bio‐inspired bidirectional‐winding origami platform enables scalable and programmable deployable structures. Double axial folding inspired by earwig hindwings and Flasher‐based hybridization create modular multilayer architectures with diverse attainable winding angles under fixed boundary conditions.
Wenyao Zhang, Chunlong Wang, Mingli Liu, Chuang Shi, Hongwei Guo, Rongqiang Liu   +5 more
wiley   +1 more source

Black Hole Quencher‐Enhanced Plasmonic Photothermal Conversion

Advanced Science, EarlyView.
Researchers have developed a universal method to boost plasmonic photothermal conversion by attaching black hole quencher (BHQ) molecules to matched metal nanostructures. This hybrid approach increases efficiency by roughly threefold, reaching up to 69.1% in the near‐infrared‐II window.
Ruiyuan Zhang, Xinru Chen, Lin Shen, Jin Li   +3 more
wiley   +1 more source

Soft, Multi‐Wavelength Photoplethysmography Enables Reliable Neonatal Blood Pressure Monitoring Via Error Stratification

Advanced Science, EarlyView.
A soft hybrid multi‐wavelength PPG wearable acquires neonatal signals. Synchronized PPG and invasive ABP data are segmented into fixed windows. A 1D‐EfficientNet model predicts segment‐level SBP and DBP. Model performance is examined with retrospective subgroup analysis across acquisition conditions.
Wenqi Shi, Lanlan Mi, Jiarong Chen, Biao Liu, Min Wang, Zisheng Dai, Bin Liu, Ruize Gao, Yunfeng Lin, Weiwei Guo, Guoxing Wang, Wenyi Luo, Cheng Chen   +12 more
wiley   +1 more source