Results 171 to 180 of about 1,061,575 (246)

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

Biological Augmentation of Arthroscopic Partial-Thickness Bursal-Sided Rotator Cuff Repair Using Minced Autologous Glenohumeral Ligament Tissue Particles. [PDF]

Arthrosc Tech
Liu H, Wang X, Mao H, Shen W.
europepmc   +1 more source

Scalable Fabrication of MOF Glass Membranes for Gas Separation via Stepwise Phase Transition

Advanced Science, EarlyView.
Metal‐organic framework (MOF) glass membranes, with their excellent processability and permanent pore structure, have great potential for gas separation applications. However, during large‐scale fabrication, defects and obvious cracks are prone to occur due to the limitations of powder processing.
Mao Ye, Yi Yang, Zibo Yang, Yuxiu Sun, De Ao, Fan Zhou, Ying Chen, Chunhui Luo, Ziyao Wang, Wenjia Sun, Yunling Jia, Wengang Huang, Jingwei Hou, Zhi Wang, Zhihua Qiao   +14 more
wiley   +1 more source

Diffractive intraocular lenses reshape 577-nm retinal laser photocoagulation spots in a model eye. [PDF]

Lasers Med Sci
Wei K, Ji F, Li Y, Dai W, Liao R.
europepmc   +1 more source

ELF5‐Mediated Enhancer–Promoter Interaction Regulates LALBA Expression in Ovine Mammary Gland

Advanced Science, EarlyView.
In the study, we systematically investigate the epigenetic mechanisms underlying lactation traits in sheep by integrating transcriptomic, chromatin accessibility, histone modification, and functional analyses. We identify a super‐enhancer at the LALBA locus and demonstrate that enhancer E4 functions as its core regulatory element.
Xinmiao Wu, Jiqing Wang, Zhiyun Hao, Mingna Li, Huimin Zhen, Yuan Liu, Guoyong Zhao, Chunyan Ren, Xuelan Zhou, Haixiong Hu, Mingjie Li, Nan Shi   +11 more
wiley   +1 more source

Gluteal Undersurface Concealed Crescent Injury Endoscopic Deep Surface Repair. [PDF]

Arthrosc Tech
Elrick BP, Kelley JZ, Welder E, Ramirez C, Judkins BL, Genuario JW.   +5 more
europepmc   +1 more source

Massively Multiplexed Photonic Chip With Cross‐Channel Fusion For Harmonized Biosensing

Advanced Science, EarlyView.
We introduce a transformative sensing platform integrating photonic multiplexing with over 10 000 sensors and a deep‐learning framework that combines domain adaptation and cross‐channel fusion for harmonized operation across heterogeneous chips. The platform achieves 99.3% identification accuracy and relative prediction errors of 10−4$^{-4}$ for ...
Ivan Saetchnikov, Elina Tcherniavskaia, Andreas Ostendorf, Anton Saetchnikov   +3 more
wiley   +1 more source

Arthroscopic Posterior Cruciate Ligament Reconstruction Using a Pedicled Semitendinosus Autograft Through a Trans-Septal Approach: A Technical Note. [PDF]

Arthrosc Tech
Alayane A, Marot V, Mouarbes D, Ortal L, Le Cunf A, Pailhe R, Cavaignac E.   +6 more
europepmc   +1 more source

Metabolic‐Redox Remodeling of Inflammatory Synovium by Mannose‐Modified Selenium Nanoparticles for Osteoarthritis Therapy

Advanced Science, EarlyView.
Elevated GLUT1‐driven glycolysis and disrupted selenoprotein‐dependent redox homeostasis drive osteoarthritic progression. Intra‐articular mannose‐modified selenium nanoparticles (M‐SeNPs) selectively target hypermetabolic synovial cells to reprogram aberrant glycolysis and restore endogenous antioxidant defenses.
Yu‐Qing Zou, Chen‐Hao Xu, Bo‐Wei Li, Leung Chan, Yi‐Di Xu, Han‐Bo Su, Rui Peng, Fang‐Ji Luo, Ya‐Chen Peng, Zhen‐Yan Li, Vincent Kam Wai Wong, Xiao‐Fei Zheng, Xing Ma, Zhen‐Gang Zha, Tianfeng Chen, Huan‐Tian Zhang   +15 more
wiley   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source