Patient Retreat in Dose Escalation for Phase I Clinical Trials With Rare Diseases
Statistics in Medicine, Volume 45, Issue 3-5, February 2026.ABSTRACT Phase I clinical trials aim to identify the maximum tolerated dose (MTD), a task that becomes challenging in rare disease due to limited patient recruitment. Traditional dose‐finding designs, which assign one dose per patient, require a sufficient sample size that may be infeasible for rare disease trials.
Jialu Fang, Guosheng Yin
wiley +1 more source
Policy gap: most child-appealing packaged food products in Canada will display a 'high in' front-of-package nutrition symbol. [PDF]
Public Health NutrJeong H +4 more
europepmc +1 more source
Modal Analysis of Water Distribution Systems With the Elastic Water Column Model
Water Resources Research, Volume 62, Issue 2, February 2026.Abstract This paper presents a modal and participation factor (PF) analysis of water distribution systems (WDSs) using the elastic water column model (EWCM). Modal analysis, widely used in other engineering fields, is adapted here to characterize the dynamic behavior of WDSs under transient conditions. By linearizing the EWCM around an operating point,
Morteza Imani +3 more
wiley +1 more source
The impact of illness perception on quality of life in lung cancer chemotherapy patients: mediating effect of fear of progression. [PDF]
Front PsychiatryXu F, Xie S, Li Q, Zhong X, Zhang J.
europepmc +1 more source
Contrasting drought responses in two grassland plant–microbe systems under climate change
Journal of Ecology, Volume 114, Issue 2, February 2026.By contrasting two plant strategies across a soil‐moisture gradient under warming and elevated CO2, this study shows how drought and climate jointly shape plant performance and associated microbiomes. The stress‐tolerant Festuca rubra responds through trait plasticity and flexible bacterial communities, whereas the competitive Lolium perenne relies ...
Gang Yang +4 more
wiley +1 more source
Dyadic coping and fear of cancer progression among patients with hepatocellular carcinoma and their spouses in China: An actor-partner interdependence model. [PDF]
Asia Pac J Oncol NursHu R, Lu H, Yu J, Zhu Z.
europepmc +1 more source
Have the environmental benefits of insect farming been overstated? A critical review
Biological Reviews, Volume 101, Issue 1, Page 163-194, February 2026.ABSTRACT Insect farming is frequently promoted as a sustainable food solution, yet current evidence challenges many environmental benefits claimed by industry proponents. This review critically examines the scientific foundation for assessing the environmental impacts of insect farming in both human food and animal feed applications.
Corentin Biteau +5 more
wiley +1 more source
Directive vs. Reductive Front-of-Pack Labels: Differences in Italian Consumers' Responses to the Nutri-Score and the NutrInform Battery. [PDF]
FoodsCela N +3 more
europepmc +1 more source