Results 71 to 80 of about 76,978 (249)

Twists in the fibrodysplasia ossificans progressiva story challenge and expand our understanding of BMP biology

open access: yesThe Journal of Clinical Investigation, 2022
Fibrodysplasia ossificans progressiva (FOP) is an ultrarare, debilitating disease in which heterotopic bone is formed in certain soft tissues. A gain-of-function variant in the cytoplasmic domain of the activin A receptor type I (ACVR1) exists in all ...
Michael T. Collins
doaj   +1 more source

Nutrient intakes and top food categories contributing to intakes of energy and nutrients-of-concern consumed by Canadian adults that would require a 'high-in' front-of-pack symbol according to Canadian labelling regulations.

open access: yesPLoS ONE, 2023
Canada recently mandated front-of-pack (FOP) labelling regulations, where foods meeting and/or exceeding recommended thresholds for nutrients-of-concern (i.e., saturated fat, sodium, and sugars) must display a 'high-in' FOP nutrition symbol.
Jennifer J Lee   +5 more
doaj   +1 more source

Diagnostic Yield of Post‐Mortem Fetal Micro‐CT for Central Nervous System Abnormalities

open access: yesPrenatal Diagnosis, EarlyView.
ABSTRACT Objectives This study demonstrates the central nervous system (CNS) abnormalities detected using fetal post‐mortem micro‐focus computed tomography (Micro‐CT), independent of whether the abnormality contributed to the main diagnosis or cause of death.
Ian C. Simcock   +5 more
wiley   +1 more source

Fear of progression, loneliness, and hope in patients with gastrointestinal cancer: a cross-sectional relational study

open access: yesFrontiers in Psychology
IntroductionIn recent years, fear of disease progression (FoP) has become one of the most common psychological problems in cancer patients. However, there are fewer studies on the FoP in patients with gastrointestinal tumors. We aimed to assess the level
Yanjun Li   +6 more
doaj   +1 more source

The serum levels of activin A and bone morphogenetic protein-4 and -6 in patients with fibrodysplasia ossificans progressiva

open access: yesOrphanet Journal of Rare Diseases, 2023
Background Fibrodysplasia ossificans progressiva (FOP) is an ultrarare and disabling genetic disorder of connective tissue characterized by congenital malformation of the great toes, and progressive heterotopic ossification (HO) in soft connective ...
Zhengqin Ye   +5 more
doaj   +1 more source

Multiscale Fields of Patterns [PDF]

open access: yes, 2014
We describe a framework for defining high-order image models that can be used in a variety of applications. The approach involves modeling local patterns in a multiscale representation of an image.
Felzenszwalb, Pedro F., Oberlin, John G.
core  

Adaptive evolution is substantially impeded by Hill–Robertson interference in Drosophila [PDF]

open access: yes, 2015
Hill–Robertson interference (HRi) is expected to reduce the efficiency of natural selection when two or more linked selected sites do not segregate freely, but no attempt has been done so far to quantify the overall impact of HRi on the rate of adaptive ...
Adam Eyre-Walker   +18 more
core   +2 more sources

Spatial and temporal variability of wet spells and their role in wet and dry summers and winters in Australia

open access: yesQuarterly Journal of the Royal Meteorological Society, EarlyView.
The change in the frequency of wet spells in tropical Australia in summer primarily contributes to the change in precipitation between wet and dry years. In the extratropics, both the frequency and intensity of wet spells are important, especially in winter.
Sunil Pariyar   +4 more
wiley   +1 more source

Sliding Doors: Frame Uptake and Rejection by Learners in a Museum‐Based Climate Learning Experience

open access: yesScience Education, EarlyView.
ABSTRACT Science education efforts that support public understanding of modern climate change are critically needed. However, implementing climate‐related learning experiences can be challenging, as public audiences tend to experience a wide range of understandings of and emotions around the issue. In light of these challenges, many scholars have posed
Lynne Zummo   +7 more
wiley   +1 more source

Fragment‐Block: A Novel Approach for Managing Variability in Software Product Lines

open access: yesSoftware: Practice and Experience, EarlyView.
ABSTRACT Objective Changes in the functionality of a software product line (SPL) can generate various issues in the SPL source code. Their complexity depends primarily on the amount of changes in the SPL source code and the internal mechanisms for managing variability. Further, modern development frameworks rely on a variety of artefacts besides source
Junior Cupe Casquina, Leonardo Montecchi
wiley   +1 more source

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