Results 211 to 220 of about 174,199 (337)

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

open access: yesFEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

open access: yesAging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal   +8 more
wiley   +1 more source

What PIs want when hiring a clinical research coordinator. [PDF]

open access: yesJ Clin Transl Sci
Fisher E, Thomas R, Choi I, McCauley L.
europepmc   +1 more source

327 Basic examination of HIRE Method in MRI

open access: bronze, 1997
高橋 俊行   +4 more
openalex   +2 more sources

Aging‐Driven Blood–Brain Barrier Dysfunction and Its Impact on CNS Cancer Susceptibility: A Comprehensive Narrative Review

open access: yesAging and Cancer, EarlyView.
Aging weakens the blood–brain barrier (BBB), increasing susceptibility to CNS cancers and complicating treatment. This review examines BBB deterioration, its impact on drug delivery, and potential interventions like targeting neuroinflammation and advanced therapies.
Quang La, Aiman Baloch, David F. Lo
wiley   +1 more source

The impact of the COVID-19 pandemic on students' views of a career in general practice: a focus group study. [PDF]

open access: yesBJGP Open
Hook Z   +8 more
europepmc   +1 more source

White Christian Nationalism in the Rural United States

open access: yesNew Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Many scholars have sought to link the rise of right‐wing populist movements, like White Christian Nationalism (WCN), to the impacts of political‐economic structural changes, such as globalization and financialization. Although these structural changes may explain some grievances, they do not explain why people express those grievances in the ...
Leland L. Glenna
wiley   +1 more source

Social Workers' Reports on Needs and Recommendations to Enhance School Safety. [PDF]

open access: yesBehav Sci (Basel)
Fensterstock N   +16 more
europepmc   +1 more source

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