Results 51 to 60 of about 174,199 (337)

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

open access: yesFEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang   +2 more
wiley   +1 more source

Singirok claims denied

open access: yesPacific Journalism Review, 1997
Claims by sacked Papua New Guinea military commander Jerry Singirok before the first mercenary Commission of Inquiry that Sandline planned to hire a journalist for A$250,000 to 'positively report on Sandline' have been strongly denied by the two named ...
Peter Cronau
doaj   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

For-hire trucking of exempt commodities by nonregulated carriers

open access: yesCalifornia Agriculture, 1966
No significant differences in the quality of trucking equipment were found in this comparative study of nonregulated, private, and regulated carriers competing for the same agricultural traffic. There were no significant vehicle-age differences among the
D Deloach, W Miklius
doaj  

Detection of cell-type-specific risk-CpG sites in epigenome-wide association studies

open access: yesNature Communications, 2019
Cellular heterogeneity is one of the major confounding factors in EWAS studies. Here the authors present a statistical method, HIgh REsolution (HIRE), which enables the detection of risk-CpG sites for individual cell types.
Xiangyu Luo, Can Yang, Yingying Wei
doaj   +1 more source

A coiled‐coil domain triggers oligomerization of MmpL10, the mycobacterial transporter of trehalose polyphleate precursor

open access: yesFEBS Letters, EarlyView.
Most MmpLs transport lipids and glycolipids of the complex mycomembrane of mycobacteria. This study shows that MmpL10 from Mycobacterium smegmatis, the transporter of the trehalose polyphosphate precursor, harbors a coiled‐coil‐like extension. Biochemical and electron microscopy studies demonstrate that the coiled‐coil enables MmpL10 to trimerize.
Julie Couston   +7 more
wiley   +1 more source

Evolutionary interplay between viruses and R‐loops

open access: yesFEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi   +4 more
wiley   +1 more source

Slow to Hire, Quick to Fire: Employment Dynamics with Asymmetric Responses to News

open access: yesJournal of Political Economy, 2014
Concave hiring rules imply that firms respond more to bad shocks than to good shocks. They provide a unified explanation for several seemingly unrelated facts about employment growth in macro- and microdata.
Cosmin L. Ilut   +2 more
semanticscholar   +1 more source

Economic Impacts of Artificial Reefs: Charlotte County, FL

open access: yesEDIS, 2012
Florida Sea Grant and UF researchers conducted a study on the economic benefits associated with artificial reef programs in a six-county region of southwest Florida, where they asked private boater and for-hire operators and clients about their ...
Betty Staugler
doaj   +3 more sources

Home - About - Disclaimer - Privacy