Results 91 to 100 of about 2,671,986 (314)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Using force covariance to derive effective stochastic interactions in dissipative particle dynamics [PDF]

, 2008
Anders Eriksson, Martin Nilsson Jacobi, Johan Nyström, Kolbjørn Tunstrøm   +3 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The Relationship Between Foot Anthropometrics, Lower-Extremity Kinematics, and Ground Reaction Force in Elite Female Basketball Players: An Exploratory Study Investigating Arch Height Index and Navicular Drop

Biomechanics
Static and dynamic foot function can be evaluated using easy-to-implement, low-cost measurements like arch height index (AHI) and navicular drop (ND). Connections between AHI/ND and lower-extremity kinematics/kinetics have largely focused on gait.
Catherine I. Cairns, Douglas W. Van Citters, Ryan M. Chapman   +2 more
doaj   +1 more source

LES FAUX-SEMBLANTS DE LA SÉDUCTION SUR QUELQUES TEXTES SOI-DISANT LÉGERS [PDF]

Studii si Cercetari Filologice: Seria Limbi Romanice, 2007
Il existe une littérature de la séduction: Ovide (L'Art d'aimer), Laclos (Les Liaisons dangereuses), Kierkegaard (Le Journal d'un séducteur), Sade (Les Cent Journées de Sodome) en forment les principaux chapitres. Que nous disent ces auteurs?
Francis CLAUDON
doaj  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

The Force of Faith: An Introduction to the Labor and Religion Special Issue [PDF]

, 2009
Joseph A. McCartin
openalex   +1 more source

Reliability and Validity of the Strain Gauge “GSTRENGTH” for Measuring Peak Force in the Isometric Belt Squat at Different Joint Angles

Sensors
Since isometric training is gaining popularity, some devices are being developed to test isometric force as an alternative to the more expensive force plates (FPs); thus, the aim of this study was to test the reliability and validity of “GSTRENGTH” for ...
Daniel Varela-Olalla, Carlos Balsalobre-Fernández, Blanca Romero-Moraleda, Sergio L. Jiménez-Sáiz   +3 more
doaj   +1 more source