Results 91 to 100 of about 7,937,994 (297)

Interpreting motion and force for narrow-band intermodulation atomic force microscopy

open access: yes, 2013
Intermodulation atomic force microscopy (ImAFM) is a mode of dynamic atomic force microscopy that probes the nonlinear tip-surface force by measurement of the mixing of multiple tones in a frequency comb.
Forchheimer, Daniel   +3 more
core   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

The gravitational self-force

open access: yes, 2004
The self-force describes the effect of a particle's own gravitational field on its motion. While the motion is geodesic in the test-mass limit, it is accelerated to first order in the particle's mass.
Poisson, Eric
core   +1 more source

The Fifth Force, the Sixth Force and the Spring Force

open access: yesApplied Physics Research, 2012
Upon  revisiting the famous Pound-Rebka-Snider experiments on the gravitational red-shift , the fifth and even the sixth force in nature are in fact the stretching and compression force of the spring , where the spring term is the cosmological constant in Einstein’s field equations.
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Force Induced DNA Melting

open access: yes, 2008
When pulled along the axis, double-strand DNA undergoes a large conformational change and elongates roughly twice its initial contour length at a pulling force about 70 pN.
Maiti, Prabal K, Santosh, Mogurampelly
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Determination of the angles of pressure in the system of limitation by optimisation of linkages [PDF]

open access: yesTransport, 2006
In the present paper a method of analytical determination of reactions and angles of pressure is considered with the four-bar linkage as an example. The determined sequence for the expression of acceleration of the points and angle acceleration of the ...
A. Demokritova, V. Demokritov
doaj  

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