Results 151 to 160 of about 1,077,204 (312)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
An analysis of the current environment within the Acquisition stage of the Weapon System Life Cycle Pertaining to the Logistics Support Analysis (LSA) process, the Logistics Support Analysis Record (LSAR), and other Logistics Support data was undertaken ...
Smith, Robert +1 more
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Childcare cost and Spanish mother’s labour force participation [PDF]
In Spain, female labour force participation is among the lowest in Europe. This paper analyzes the extent to which female labour force participation is affected by the cost of formal childcare.
Cristina Borra
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Enhanced cutting force model in micro-milling incorporating material separation criterion
Precisely discerning the material separation criterion in micro-machining remains challenging yet crucial for accurately predicting cutting forces by accounting for shearing and ploughing effects.
Zhang, Da-Wei +5 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
, 2022 This presentation describes a collaborative research effort between the Australian National University and Defence Science & Technology (DST) Group to develop a benefit realisation model for Defence investments in major acquisition projects, force ...
Johns, Kevin +4 more
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
An analysis of the current environment within the Acquisition stage of the Weapon System Life Cycle Pertaining to the Logistics Support Analysis (LSA) process, the Logistics Support Analysis Record (LSAR), and other Logistics Support data was undertaken ...
Smith, Robert +1 more
core
An Architecture Model for Multimodal Interfaces with Force Feedback I.14 Virtual Reality 2
, 1995 Multimodal interfaces with force feedback pose new problems both in terms of their design and for hardware and software implementation. The first problem is to design and build force-feedback pointing devices that permit users both to select and ...
C. Ramstein
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