Results 91 to 100 of about 1,030,724 (297)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Nihon Kikai Gakkai ronbunshu, 2018 This paper presents experiments and an analysis of the self-excited vibration of a plate supported by air pressure. In the analysis, the unsteady fluid force acting on the plate is calculated based on the basic equation of a two-dimensional gap flow ...
Masakazu TAKEDA, Masahiro WATANABE
doaj +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Estimation of the noise generated by the random impacts on a thin plate
Nihon Kikai Gakkai ronbunshu, 2019 When one rides a car on a gravel road, a noise due to collision of gravels rolled up by tires makes him uncomfortable. The collisions are assumed as random impacts with respect to mass, collision time, position, velocity, angle and so on.
Yuya NAGASHIMA +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source
Boundary forces and plate velocities
Geophysical Research Letters, 1981 The notion that plate motions result from forces associated with plate boundaries implies that average plate velocities in a mantle (hot spot) frame of reference are systematically related to the nature and geometry of plate boundaries, and to the proportion of continental lithosphere included in the plates. Several simple, linear models relating plate
openaire +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Repulsive Casimir interaction: Boyer oscillators at nanoscale
, 2015 We study the effect of temperature on the repulsive Casimir interaction between an ideally permeable and an ideally polarizable plate {\it in vacuo}. At small separations or for low temperatures the quantum fluctuations of the electromagnetic field give ...
Dogahe, Badrosadat Ojaghi +2 more
core +1 more source
The Casimir force between rough metallic plates
Europhysics Letters (EPL), 2003 The Casimir force between two metallic plates is affected by their roughness state. This effect is usually calculated through the so-called `proximity force approximation' which is only valid for small enough wavevectors in the spectrum of the roughness profile.
Genet, Cyriaque +3 more
openaire +3 more sources