Results 91 to 100 of about 570,562 (302)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

A High Performance Sensor for Triaxial Cutting Force Measurement in Turning

Sensors, 2015
This paper presents a high performance triaxial cutting force sensor with excellent accuracy, favorable natural frequency and acceptable cross-interference for high speed turning process.
You Zhao, Yulong Zhao, Songbo Liang, Guanwu Zhou   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A Fiber-Optic Six-Axis Force Sensor Based on a 3-UPU-Compliant Parallel Mechanism

Applied Sciences
Traditional six-axis force sensors are mostly based on resistance strain, piezoelectricity and capacitors, which have poor resistance to electromagnetic interference.
Jiachen Ma, Siyi Chen, Haiting Di, Ke Liu   +3 more
doaj   +1 more source

A Fiber Bragg Grating Anchor Rod Force Sensor for Accurate Anchoring Force Measuring

IEEE Access, 2020
This paper presents a novel anchor rod force sensor based on fiber Bragg grating (FBG) for accurate anchoring force measurement. A special FBG strain sensor with enhanced sensitivity has been designed and embedded in the centre line of an elastic ...
Jianjun Fu, Yongxing Guo, Peng Li
doaj   +1 more source

Particulate and aerosol detector [PDF]

, 1976
A device is described for counting aerosols and sorting them according to either size, mass or energy. The component parts are an accelerator, a capacitor sensor and a readout.
Brooks, A. D., Donovan, R. P., Kinard, W. H., Monteith, L. K., Oneil, R. L., Wortman, J. J.   +5 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Development of Wearable Sheet-Type Shear Force Sensor and Measurement System that is Insusceptible to Temperature and Pressure

Sensors, 2017
A sheet-type shear force sensor and a measurement system for the sensor were developed. The sensor has an original structure where a liquid electrolyte is filled in a space composed of two electrode-patterned polymer films and an elastic rubber ring ...
Shigeru Toyama, Yasuhiro Tanaka, Satoshi Shirogane, Takashi Nakamura, Tokio Umino, Ryo Uehara, Takuma Okamoto, Hiroshi Igarashi   +7 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Research of a Novel 3D Printed Strain Gauge Type Force Sensor

Micromachines, 2018
A 3D printed force sensor with a composite structure developed by combining digital light processing (DLP) based printing and inkjet printing technologies is described in this paper.
Mingjie Liu, Qi Zhang, Yiwei Shao, Chuanqi Liu, Yulong Zhao   +4 more
doaj   +1 more source