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Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers   +19 more
wiley   +1 more source

Clinical Practice Guideline for Evaluation and Management of Peripheral Nervous System Manifestations in Sjögren's Disease

open access: yesArthritis Care &Research, EarlyView.
Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo   +88 more
wiley   +1 more source
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MEG-compatible force sensor

Journal of Neuroscience Methods, 2005
By use of an insulating material we constructed a strain gauge based sensor to measure isometric forces in parallel with magneto-encephalographic recordings (i.e. without interference). The sensor can be used in different geometries to measure force production in different dimensions.
Boonstra, T.W.   +5 more
openaire   +3 more sources

Data glove with a force sensor

IMTC 2001. Proceedings of the 18th IEEE Instrumentation and Measurement Technology Conference. Rediscovering Measurement in the Age of Informatics (Cat. No.01CH 37188), 2002
This paper presents a data glove equipped with a force sensor. The construction and the electronic circuit are also described. The glove is selected to be a rubber-coated cotton glove. The sensors are firmly attached to the rubber-coated glove using cyanoacrilic glue.
Kostas N. Tarchanidis, John N. Lygouras
openaire   +1 more source

DNA: A Programmable Force Sensor

Science, 2003
Direct quantification of biomolecular interaction by single-molecule force spectroscopy has evolved into a powerful tool for materials and life sciences. We introduce an approach in which the unbinding forces required to break intermolecular bonds are measured in a differential format by comparison with a known reference bond (here, a short DNAduplex).
Albrecht, C.   +9 more
openaire   +3 more sources

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