Results 71 to 80 of about 529,798 (193)

AFM pulling and the folding of donor-acceptor oligorotaxanes: phenomenology and interpretation

, 2009
The thermodynamic driving force in the self-assembly of the secondary structure of a class of donor-acceptor oligorotaxanes is elucidated by means of molecular dynamics simulations of equilibrium isometric single-molecule force spectroscopy AFM ...
Callen H. B., George C. Schatz, Hill T. L., Ignacio Franco, Mark A. Ratner, Ponder J.   +5 more
core   +1 more source

Topography and mechanical properties of single molecules of type I collagen using atomic force microscopy [PDF]

, 2005
Although the mechanical behavior of tendon and bone has been studied for decades, there is still relatively little understanding of the molecular basis for their specific properties.
Bozec, L., Horton, M.
core  

Optical tweezers force–fluorescence spectroscopy in investigations of DNA replication

Advances in Physics: X
The last three decades have seen major breakthroughs in single-molecule biophysical techniques, which have advanced our understanding of biological processes across various scales from molecules to cells and tissues.
Zhaowei Liu, Colleen C. Caldwell, Longfu Xu, Fatema Zahra Rashid, Gijs J. L. Wuite   +4 more
doaj   +1 more source

Structure and Nanomechanics of Model Membranes by Atomic Force Microscopy and Spectroscopy: Insights into the Role of Cholesterol and Sphingolipids

Membranes, 2016
Biological membranes mediate several biological processes that are directly associated with their physical properties but sometimes difficult to evaluate.
Berta Gumí-Audenis, Luca Costa, Francesco Carlá, Fabio Comin, Fausto Sanz, Marina I. Giannotti   +5 more
doaj   +1 more source

Optimal evaluation of single-molecule force spectroscopy experiments

, 2007
The forced rupture of single chemical bonds under external load is addressed. A general framework is put forward to optimally utilize the experimentally observed rupture force data for estimating the parameters of a theoretical model.
H. Cramér, Peter Reimann, Sebastian Getfert, T. M. Cover   +3 more
core   +1 more source

Directly measuring single molecule heterogeneity using force spectroscopy

, 2016
One of the most intriguing results of single molecule experiments on proteins and nucleic acids is the discovery of functional heterogeneity: the observation that complex cellular machines exhibit multiple, biologically active conformations.
Hinczewski, Michael, Hyeon, Changbong, Thirumalai, D.   +2 more
core  

HIV restriction factor APOBEC3G binds in multiple steps and conformations to search and deaminate single-stranded DNA

eLife, 2019
APOBEC3G (A3G), an enzyme expressed in primates with the potential to inhibit human immunodeficiency virus type 1 (HIV-1) infectivity, is a single-stranded DNA (ssDNA) deoxycytidine deaminase with two domains, a catalytically active, weakly ssDNA binding ...
Michael Morse, M Nabuan Naufer, Yuqing Feng, Linda Chelico, Ioulia Rouzina, Mark C Williams   +5 more
doaj   +1 more source

Localized ferromagnetic resonance force microscopy in permalloy-cobalt films

, 2009
We report Ferromagnetic Resonance Force Microscopy (FMRFM) experiments on a justaposed continuous films of permalloy and cobalt. Our studies demonstrate the capability of FMRFM to perform local spectroscopy of different ferromagnetic materials ...
Akhadov, E., Cha, K. C., Hammel, P. C., Martin, I., Movshovich, R., Nazaretski, E., Obukhov, Yu., Pelekhov, D. V.   +7 more
core   +1 more source

Nonlinear Dynamic Force Spectroscopy

, 2016
Dynamic force spectroscopy (DFS) is an experimental technique that is commonly used to assess information of the strength, energy landscape, and lifetime of noncovalent bio-molecular interactions. DFS traditionally requires an applied force that increases linearly with time so that the bio-complex under investigation is exposed to a constant loading ...
Björnham, Oscar, Andersson, Magnus
openaire   +2 more sources

Nanoscale Analysis beyond Imaging by Atomic Force Microscopy: Molecular Perspectives on Oncology and Neurodegeneration

Small Science
Nanobiomedicine promises to revolutionize life quality and expectancy of patients with cognitive impairment and cancer malignancies, via unraveling key molecular processes related to their onset useful as biomarkers of disease to develop and improve the ...
Carlos Marcuello, KeeSiang Lim, Giacomo Nisini, Vadim S. Pokrovsky, João Conde, Francesco Simone Ruggeri   +5 more
doaj   +1 more source