Results 131 to 140 of about 264 (215)

Efficacy and Safety of Dupilumab in Chinese Adult Patients With Chronic Rhinosinusitis With Nasal Polyps: A Randomized, Placebo‐Controlled, Phase III Trial

open access: yesAllergy, EarlyView.
Dupilumab significantly improved nasal polyp score, nasal congestion, olfaction, total symptom score, and disease‐specific quality of life in Chinese patients with uncontrolled CRSwNP. Incidence of treatment‐emergent adverse events was similar between dupilumab and placebo.
Mu Xian   +18 more
wiley   +1 more source

Clinical Features of Cellular Senescence Pathways in Severe Asthma

open access: yesAllergy, EarlyView.
In bronchial biopsies, SASP and p53 pathway enrichment scores are elevated in severe asthma versus non‐severe asthma and healthy controls. SASP enrichment is validated in the independent NOVA cohort. SASP enrichment is also elevated in nasal brushings of participants with nasal polyps, independently of asthma status.
Woo‐Jung Song   +122 more
wiley   +1 more source

Effect Of Pranayama On Peak Expiratory Flow Rate & Forced Vital Capacity Among Middle Aged Females

open access: yes
The purpose of the study was to investigate the effects of Pranayama on Peak Expiratory Flow Rate (PEFR) and Forced Vital Capacity (FVC) among middle aged female (Age ranging 30 to 60 years). There was an Experimental Group and a Control Group. According to age the subjects were divided into two groups i.e., Young Adult (YA) age ranging from 30 to 45 ...
openaire   +2 more sources

Efficacy and Safety of Intralymphatic Immunotherapy With Grass Allergoid and Microcrystalline Tyrosine: A Double‐Blind Randomised Placebo‐Controlled Trial

open access: yesAllergy, EarlyView.
This is the first randomised placebo‐controlled trial of intralymphatic immunotherapy using a microcrystalline tyrosine‐adjuvanted grass pollen allergoid. Three ultrasound‐guided ILIT injections were well tolerated and reduced combined symptom‐medication scores compared with placebo. The findings support further optimisation and clinical development of
Lara Šošić   +13 more
wiley   +1 more source

Cache‐Cache: Dans les souffles du Grand Fleuve…

open access: yesAnthropology of Consciousness, EarlyView.
ABSTRACT Between ventriloquism and divination, devotion and consecration, an old and sublime marine game unfolds each day, with living breaths shared in the waters of the great river. In Tadoussac, on the north shore of the St. Lawrence Estuary, at the mouth of the Saguenay, the rumor of whales has long resonated.
David Jaclin   +3 more
wiley   +1 more source

From Rating System to Thought Leadership: The Evolution of the Canada Green Building Council

open access: yesBusiness Ethics, the Environment &Responsibility, EarlyView.
ABSTRACT Green Building Social Movement Organizations encourage the adoption of green buildings, primarily by promoting sustainability rating tools. While numerous papers have explored the market impact of these sustainability rating tools, very few have examined either the lengthy and protracted process of their selection and enrollment by ...
J. J. McArthur   +2 more
wiley   +1 more source

Identification of predictive factors for reversal of cerebral vasculopathy in an original longitudinal cohort study in newborns with sickle cell anaemia

open access: yesBritish Journal of Haematology, EarlyView.
Summary Cerebral macrovasculopathy (CV) is a major complication in children with sickle cell anaemia (SCA) and usually requires a long‐term transfusion programme (TP) to prevent stroke. This study aimed to identify factors predicting reversal of CV on TP in a single‐centre newborn cohort. Among 375 patients, 50 presented CV and received TP.
Julie Sommet   +16 more
wiley   +1 more source

The discovery and development of ensifentrine: A novel inhaled dual PDE3/4 inhibitor having ‘bifunctional’ bronchodilator and anti‐inflammatory activity

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Ensifentrine (formerly called RPL 554) is a novel, first in class, inhaled bifunctional dual PDE3/4 inhibitor for the treatment of chronic respiratory diseases. Ensifentrine exhibits both bronchodilation via PDE3 inhibition and anti‐inflammatory activity via PDE4 inhibition.
Clive Page
wiley   +1 more source

Effects of Noninvasive Cervical Vagal Nerve Stimulation on Cognitive Performance But Not Brain Activation in Healthy Adults

open access: yesNeuromodulation: Technology at the Neural Interface, EarlyView., 2020
Abstract Objectives While preliminary evidence suggests that noninvasive vagal nerve stimulation (nVNS) may enhance cognition, to our knowledge, no study has directly assessed the effects of nVNS on brain function and cognitive performance in healthy individuals.
Ruth Klaming   +3 more
wiley   +1 more source

Inflammatory Mediators Associated With Corticosteroid Responsiveness During Asthma Attacks

open access: yesClinical &Experimental Allergy, EarlyView.
ABSTRACT Higher baseline sputum/serum eotaxin‐3 and serum IL‐5 levels were associated with greater FEV1 improvement following OCS during asthma attacks. Corticosteroid‐induced inflammatory modulation differed across T2 phenotypes during asthma attacks.
Carlos Celis‐Preciado   +11 more
wiley   +1 more source

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