Results 91 to 100 of about 118,717 (344)

Medication adherence during the run‐in phase of clinical trials: A systematic review of methodological and reporting rigour

British Journal of Clinical Pharmacology, EarlyView.
Aims Trial run‐in phases are sometimes used to select adherent participants as a strategy to enrich trials, but the methods employed lack clear regulatory guidance and there are concerns about the transparency of reporting. This review aims to characterize the methods used for adherence measurement and public reporting of run‐in studies.
Non Davies, Bernard Vrijens, Daniel F. B. Wright, Dyfrig A. Hughes   +3 more
wiley   +1 more source

AZD0449, an inhaled JAK1 inhibitor, in healthy participants and patients with mild asthma

British Journal of Clinical Pharmacology, EarlyView.
Aims Inhaled corticosteroids (ICS) plus bronchodilator are recommended for the treatment of asthma. Targeting the JAK1‐dependent pathway may be an alternative for asthma management in patients with incomplete response to ICS. The aim of this study was to investigate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of AZD0449, a
Anna Lundahl, Rod Hughes, Joachim Almquist, David Close, Jukka Mäenpää, Ulrika Tehler, Tina Jellesmark Jensen, Szilárd Nemes, Anne‐Kristina Mercier, Zala Jevnikar, Pablo Forte Soto, Dave Singh   +11 more
wiley   +1 more source

Eficácia do formoterol na reversão imediata do broncoespasmo Efficacy of inhaled formoterol in reversing bronchoconstriction

Jornal Brasileiro de Pneumologia, 2006
OBJETIVO: Avaliar efetividade e rapidez de ação do formoterol liberado através de inalador para pó seco na reversão de broncoespasmo induzido pela metacolina.
Adalberto Sperb Rubin, Christiano Perin, Liliana Pelegrin, Juliana Cardozo Fernandes, Luiz Carlos Corrêa da Silva   +4 more
doaj   +1 more source

Bronchial responsiveness and the reproducibility of forced expiratory volume in one second.

Scandinavian Journal of Work, Environment & Health, 1993
Although poorly reproducible spirometric tests, "test failures," are associated with respiratory morbidity, it is not clear what causes them. Bronchial responsiveness was examined in relation to test failure for forced expiratory volume in 1 s (FEV1.0) (1979 definition of the American Thoracic Society) in 249 bakers, 165 chemical industry workers, and ...
Venables, K, Graneek, B, Taylor, A
openaire   +4 more sources

Corn cob pyrolysis: A systematic literature review of methods and applications

The Canadian Journal of Chemical Engineering, EarlyView.
Mapping the research landscape of corn cob pyrolysis. Abstractas The agricultural sector is experiencing a surge in waste generation due to population growth, creating an urgent need to convert byproducts into value‐added products. Maize (Zea mays L.), a leading global crop, produces significant byproducts, such as corn cob, which are often undervalued.
Vilmar Steffen, Maiquiel Schmidt de Oliveira, Lais da Silva Pego Hericks, Schaline Winck Alberti, Marlon Henrique da Silva, Edson Antonio da Silva   +5 more
wiley   +1 more source

Effectiveness and Safety of Oral Triamcinolone in the Management of Acute Exacerbations of Asthma: A Prospective Interventional Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Acute exacerbation of asthma leads to increased morbidity, mortality, and healthcare costs. Oral Corticosteroids (OCS) are critical in the management of asthma exacerbations; however, the response varies between patients.
Santhalingam Balamurugan
doaj   +1 more source

Effect of Environmental Change while Climbing Mt. Daisen on Forced Vital Capacity and Forced Expiratory Volume % in Young Women [PDF]

, 2011
The aim of the present study was to clarify the effects of environmental change while climbing Mt. Daisen on forced vital capacity and forced expiratory volume % in young women in summer.
Arakane Keita, Baik Wooram, Fujiwara Yuko, Furumoto Kayo, Hayashi Sotaro, Ishida Yasuo, Kawano Hiroshi, Nishimura Kazuki, Nose Yuka, Ono Kumiko, Onodera Sho, Saito Tatsuya, Seki Kazutoshi, Shiiba Daisuke, Takagi Yusuke, Takahara Terumasa, Yamaguchi Hidetaka, Yoshioka Akira   +17 more
core   +1 more source

Cardiorespiratory fitness and sports activities in children and adolescents with solitary functioning kidney [PDF]

, 2016
Background: An increasing number of children with chronic disease require a complete medical examination to be able to practice physical activity. Particularly children with solitary functioning kidney (SFK) need an accurate functional evaluation to ...
DE CASTRO, Giovanna, DUSE, MARZIA, Falsaperla, R, FAVORITI, ALESSANDRA, LAMBIASE, CATERINA, LUBRANO, Riccardo, Paoli, S, Ricupito, F, TANCREDI, Giancarlo, Vitaliti, G, ZICARI, Anna Maria   +10 more
core   +2 more sources

Clinical Trials With Pragmatic Elements: A Review of Use Cases and Real‐World Data Utilization

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical trials with pragmatic elements can capture diverse patient populations, enable efficient follow‐up, and reflect routine clinical practices; yet there is limited understanding of their design features, characteristics, and use of real‐world data (RWD). Based on a targeted search of PubMed/EMBASE (Jan‐2016 to Jul‐2024), a review was conducted to
Le Su, Lei Chen, Seema Betigeri, Nancy Dreyer, Helga Gardarsdottir, Rachele Hendricks‐Sturrup, Mehmet Burcu   +6 more
wiley   +1 more source

Do patients with suspected heart failure and preserved left ventricular systolic function suffer from "diastolic heart failure" or from misdiagnosis? A prospective descriptive study [PDF]

, 2000
OBJECTIVES: To characterise the clinical features of patients with suspected heart failure but preserved left ventricular systolic function to determine if they have other potential causes for their symptoms rather than being diagnosed with 'diastolic ...
Caruana, L., Davie, A.P., McMurray, J., Petrie, M.C.   +3 more
core   +2 more sources