Results 41 to 50 of about 3,966,093 (248)

Humanitarian Innovation Project [PDF]

, 2014
The Humanitarian Innovation Project (HIP) www.oxhip.org is housed within the Refugee Studies Centre at the University of Oxford and focuses specifically on the refugee ...
Review, Forced Migration
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Comparison between forced vital capacity performed with lower limbs in neutral position (standard) or crossed.

, 2014
Data shown as median (interquartile range 25%–75%). FVC: forced vital capacity. FEV1: forced expiratory volume in the first second. PEF: peak expiratory flow. FEF25–75%: forced expiratory flow between 25% and 75% of FVC.
Leila Donária (632431), Fabio Pitta (632434), Larissa Martinez (632430), Vanessa Suziane Probst (632432), Luciana Sipoli (632429), Graciane Laender Moreira (632433)   +5 more
core   +1 more source

Inclusion of Peak Expiratory Flow for Selection of the 'Best' Forced Vital Capacity Manoeuvre [PDF]

, 1996
OBJECTIVE: To assess four different criteria for selecting the 'best' forced vital capacity (FVC) manoeuvre to be used for clinical diagnostic ...
Giovanni Viegi, Paolo Paoletti, Alessandro Celi, Francesco Pistelli, Mariella Vellutini, Giuseppe Pistelli, Laura Carrozzi, Francesco Di Pede, Carlo Giuntini   +8 more
core   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

Prognostic Role of Pulmonary Function in Patients With Heart Failure With Reduced Ejection Fraction

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Both ventilatory abnormalities and pulmonary hypertension (PH) are frequently observed in patients with heart failure with reduced ejection fraction.
Hao‐Chih Chang, Wei‐Ming Huang, Wen‐Chung Yu, Hao‐Min Cheng, Chao‐Yu Guo, Chern‐En Chiang, Chen‐Huan Chen, Shih‐Hsien Sung   +7 more
doaj   +1 more source

Comparison between forced vital capacity performed without (standard) or with upper limbs support.

, 2014
Data shown as median (interquartile range 25%–75%). FVC: forced vital capacity. FEV1: forced expiratory volume in the first second. PEF: peak expiratory flow.
Leila Donária (632431), Fabio Pitta (632434), Larissa Martinez (632430), Vanessa Suziane Probst (632432), Luciana Sipoli (632429), Graciane Laender Moreira (632433)   +5 more
core   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source