Results 111 to 120 of about 1,834,325 (334)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

On the Nearshore Significant Wave Height Inversion from Video Images Based on Deep Learning

Journal of Marine Science and Engineering
Accurate observation of nearshore waves is crucial for coastal safety. In this study, the feasibility of extracting wave information from wave video images captured by shore-based cameras using deep learning methods was explored, focusing on inverting ...
Chao Xu, Rui Li, Wei Hu, Peng Ren, Yanchen Song, Haoqiang Tian, Zhiyong Wang, Weizhen Xu, Yuning Liu   +8 more
doaj   +1 more source

Forecaster’s utility and forecasts coherence [PDF]

, 2018
I provide general frequentist framework to elicit the forecaster’s expected utility based on a Lagrange Multiplier-type test for the null of locality of the scoring rules associated to the probabilistic forecast. These are assumed to be observed transition variables in a nonlinear autoregressive model to ease the statistical inference.
openaire   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

The Storm Surge Inundation Risk Warning System for Xiamen

Haiyang Kaifa yu guanli, 2022
In order to improve the capability to defend against typhoon storm surge disaster risk and assist government departments in marine disaster prevention and mitigation in Xiamen City, this paper developed a storm surge inundation risk warning system based ...
Fangchao YUAN, Wenzhou ZHANG, Yuying YE, Shimin ZHANG   +3 more
doaj  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Comparison of AI and NWP Models in Operational Severe Weather Forecasting: A Study on Tropical Cyclone Predictions

Journal of Geophysical Research: Machine Learning and Computation
Data‐driven artificial intelligence weather prediction (AIWP) models show great potential in weather forecasts, facilitating paradigm shift of prediction from a deductive to an inductive inference.
Yang Shi, Rong Hu, Naigeng Wu, Hualong Zhang, Xinhang Liu, Zhilin Zeng, Jing Zhu, Pucheng Han, Cong Luo, Hongyan Zhang, Jie He, Xiaoming Shi   +11 more
doaj   +1 more source

The Galactic Center Weather Forecast

, 2012
In accretion-based models for Sgr A* the X-ray, infrared, and millimeter emission arise in a hot, geometrically thick accretion flow close to the black hole.
Dolence, Joshua C., Gammie, Charles F., Moscibrodzka, Monika, Shiokawa, Hotaka   +3 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Characteristics of the underground hot water circulation system western Yunnan Yingjiang basin and resources development potential

Carsologica Sinica
The geothermal energy of the Yingjiang basin is located within Yingjiang–Longchuan high-temperature hot water belt, which is part of Gaoligongshan–Tengchong sub-area of high-temperature hot water region of western Yunnan.
Hua ZHANG, Raosheng HE, Xiaobo KANG, Yingbin YANG, Qin LI, Yu GAO, Junrong ZHOU, Jinlong CHAI   +7 more
doaj   +1 more source