Results 261 to 270 of about 2,067,646 (378)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Forecasting Energy Demand in Quicklime Manufacturing: A Data-Driven Approach. [PDF]

Sensors (Basel)
Leon-Medina JX, Fonseca Gonzalez JE, Callejas Rodriguez NY, González Niño ME, Hernández Moreno SA, Pineda-Munoz WA, Siachoque Celys CP, Umbarila Suarez B, Pozo F.   +8 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

A novel parametric scaled exponential linear unit activation function for deep residual networks in short-term load forecasting. [PDF]

Sci Rep
Liu J, Ahmad FA, Samsudin K, Hashim F, Abidin Ab Kadir MZ.   +4 more
europepmc   +1 more source

Severity influences categorical likelihood communications: A case study with Southeast Asian weather forecasters [PDF]

Alice Liefgreen, Sarah C. Jenkins, Sazali Osman, Lorenzo A. Moron, Maria Cecilia A. Monteverde, Esperanza. O. Cayanan, Lam Hoang, Diep Quang Tran, Huong Ngo, Agie Wandala Putra, Riefda Novikarany, Sefri Ayuliana, Rebecca Beckett, Adam J. L. Harris   +13 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Estimating a physiological threshold to oxygen and temperature from marine monitoring data reveals challenges and opportunities for forecasting distribution shifts [PDF]

Julia Indivero, Sean C. Anderson, Lewis A. K. Barnett, Timothy E. Essington, Eric J. Ward   +4 more
openalex   +1 more source

BIOMOD – a platform for ensemble forecasting of species distributions

, 2009
W. Thuiller, Bruno Lafourcade, Robin Engler, M. Araújo   +3 more
semanticscholar   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A multi-source behavioral data framework for interpretable urban tourism forecasting. [PDF]

Sci Rep
Nie Z, Nie Z.
europepmc   +1 more source