Results 171 to 180 of about 178,867 (312)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Ensemble forecasts of COVID-19 activity to support Australia's pandemic response: 2020-22. [PDF]

PLoS Comput Biol
Moss R, Tobin RJ, O'Hara-Wild M, Adekunle AI, Liu D, South T, Morris DJ, Ryan GE, Hao T, Babu A, Senior KL, Wood JG, Golding N, Ross JV, Dawson P, Hyndman RJ, Price DJ, McCaw JM, Shearer FM.   +18 more
europepmc   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Fiscal sustainability and the accuracy of macroeconomic forecasts: do supranational forecasts rather than government forecasts make a difference? [PDF]

Credible fiscal plans that aim at restoring fiscal sustainability will be essential to counter the present increase in debt levels all across Europe. The macroeconomic scenario of such plans will be crucial.
Carlos Fonseca Marinheiro
core  

Weather forecasts become more important for reducing mortality as the climate warms. [PDF]

Proc Natl Acad Sci U S A
Shrader JG, Thies S, Bakkensen L, Linsenmeier M, Lemoine D.   +4 more
europepmc   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Estimating fundamental cross-section dispersion from fixed event forecasts [PDF]

A couple of recent papers have shifted the focus towards disagreement of professional forecasters. When dealing with survey data that is sampled at a frequency higher than annual and that includes only fixed event forecasts, e.g.
Jonas Dovern, Ulrich Fritsche
core  

Understanding the value of a forecast using an online game. [PDF]

PLoS One
Yiannakoulias N, Slavik CE.
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Retrospective evaluation of trained and untrained probabilistic ensemble forecasts for influenza hospital admissions - United States, 2022-2025. [PDF]

Infect Dis Model
Frutos AM, Hines A, Shandross L, Ray EL, Reich NG, Borchering RK, Biggerstaff M.   +6 more
europepmc   +1 more source