Results 11 to 20 of about 85,966 (198)

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance

FEBS Open Bio, EarlyView.
In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley   +1 more source

Investigation of Solid‐Solution Phase Formation in AlCuNiSi Medium Entropy Alloys and its Effect on Microstructural, Thermal, and Microhardness Properties

Advanced Engineering Materials, EarlyView.
This study focuses on synthesizing equiatomic AlCuNiSi medium‐entropy alloys using mechanical alloying for advanced industrial applications. Continuous milling leads to grain refinement and the formation of stable BCC/FCC solid‐solution phases, resulting in enhanced mechanical properties. A unique Si‐rich solid‐solution phase is observed, which did not
Mustafa Okumuş, Mehmet Emin Demir, Celal Onat   +2 more
wiley   +1 more source

Conducting Polymer Microelectrode Arrays for Simultaneous Electrophysiology and Advanced Brain Imaging

Advanced Functional Materials, EarlyView.
A flexible micro‐electrocorticography array with PEDOT:SS electrodes is shown to be compatible with ultra‐high magnetic field MRI up to 9.4 T. Multimodal brain monitoring is demonstrated by performing simultaneous blood oxygen level‐dependent functional MRI in parallel with electrophysiology.
Sagnik Middya, Alejandro Carnicer‐Lombarte, Stephen Sawiak, Sam Hilton, Vincenzo F Curto, Damiano G Barone, Gabriele S Kaminski Schierle, George G Malliaras   +7 more
wiley   +1 more source

Advanced Micro‐OLED Integration on Thin and Flexible Polymer Neural Probes for Targeted Optogenetic Stimulation

Advanced Functional Materials, EarlyView.
This paper introduces a flexible neural probe with integrated micro‐OLEDs on a flexible substrate for the first time, featuring 8 micro‐OLEDs and recording electrodes for optogenetics. It uses advanced encapsulation and an IAI anode for durability, emitting 470 nm light for ChR2 activation, enabling high‐resolution, minimally invasive stimulation ...
Somin Lee, Mi Kyung Kim, Seonil Kwon, Jia Chee Leong, Byeongju Noh, Junhee Sim, Eun Gyo Jeong, Hyunjoo J. Lee, Kyung Cheol Choi   +8 more
wiley   +1 more source

Laser‐Induced Graphene‐Assisted Patterning and Transfer of Silver Nanowires for Ultra‐Conformal Breathable Epidermal Electrodes in Long‐Term Electrophysiological Monitoring

Advanced Functional Materials, EarlyView.
This study presents a novel method using laser‐induced graphene (LIG) to enable high‐yield transfer of silver nanowire (AgNW) networks onto ultra‐low modulus, breathable silicone substrates. This approach creates ultra‐conformal epidermal electrodes (≈50 µm) for long‐term, high‐fidelity electrophysiological monitoring, even in challenging conditions ...
Jiuqiang Li, Senhao Zhang, Jun Zhong, Benkun Bao, Kai Guo, Yingying Zhang, Kerong Yang, Yao Tong, Donghai Qiu, Hongbo Yang, Huanyu Cheng   +10 more
wiley   +1 more source

Anionic Citrate‐Based 3D‐Printed Scaffolds for Tunable and Sustained Orthobiologic Delivery to Enhance Tissue Regeneration

Advanced Functional Materials, EarlyView.
A potent anionic citric acid‐based 3D‐printed scaffold is developed for the sustained and controlled release of orthobiologics to enhance orthopedic therapeutic efficacy. Comprehensive in vivo studies demonstrated effective bone fusion and high safety at a low dose of BMP‐2 delivered by the system, establishing it as a promising platform for safe ...
Se‐Hwan Lee, Ruqiang Lu, Andrew House, Zizhao Li, Lindsey Hammond Burton, Katie Josephine Sikes, Lynn Marie Pezzanite, Drew William Koch, Kevin Michael Labus, Ben Gadomski, Jeremiah Easley, Richard Tuan Tran, Su Chin Heo   +12 more
wiley   +1 more source