Results 221 to 230 of about 63,434 (349)

Diltiazem N‐oxide, a novel ischaemia‐activated prodrug, prevents ischaemia‐induced ventricular fibrillation without off‐target adverse effects

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ventricular fibrillation (VF) in coronary heart disease accounts for up to 70% of sudden cardiac death. We examined whether diltiazem N‐oxide (DNO) has ischaemia‐selective antiarrhythmic activity. Experimental Approach Randomised and blinded experiments were performed in rat isolated hearts and in anaesthetised rats to ...
Louise M. Hesketh, Gabriel A. Watson, Francesca Mazzacuva, Zoe Hoare, Thomas R. Eykyn, Michael J. Curtis   +5 more
wiley   +1 more source

Joint Angular Excursions and Angular Range Utilization During Stance-Phase Locomotion in Terrestrial Mammals: A Comparative Morphofunctional Data Set. [PDF]

J Exp Zool A Ecol Integr Physiol
Medina-González P.
europepmc   +1 more source

CKLF‐like MARVEL transmembrane domain‐containing superfamily 8 (CMTM8) promotes Notch signalling to maintain CD8+ T cell‐ and NK cell‐dependent tumour immune escape

British Journal of Pharmacology, EarlyView.
Background and Purpose The CKLF‐like MARVEL transmembrane domain containing superfamily (CMTM) has an important role in tumour immunity. The role of CMTM8 in tumour immune microenvironment (TIME) remains unknown. The aim was to investigate the relationship between CMTM8 and antitumour immunity. Experimental Approach Lentiviral system was established to
Fanglin Li, Longhua Gu, Runqiu Chen, Zhiying Li, Rong Zhang, Chen Chen, Yi Liu, Xinhang Zheng, Yiting Wang, Shanna Wu, Jianhua Sun, Jing Chen, Bingshun Wang, Likun Gong, Yiru Long   +14 more
wiley   +1 more source

Exosomes derived from human umbilical cord mesenchymal stem cells attenuate neuroinflammation in intracerebral hemorrhage rats by modulating lactylation modification. [PDF]

J Transl Med
Zhang A, Zhang Z, Liu R, Zhao Z, Liu L.
europepmc   +1 more source

Clinical‐Grade Human Induced Pluripotent Stem Cell‐Derived Neural Precursor Cells Restore Motor Function and Preserve Striatal Integrity in a Quinolinic Acid‐Lesioned Rat Model of Huntington's Disease

Cell Proliferation, EarlyView.
Clinical‐grade HLA‐homozygous iPSC‐derived neural precursor cells restore motor function, rebuild striatal circuitry and reduce neuroinflammation in QA‐lesioned rats. These findings demonstrate robust neuronal replacement and microenvironment modulation, supporting their potential as a regenerative therapy for Huntington's disease.
Hyeonjoong Jeon, Il‐Shin Lee, Sanghun Lee, Hyo Chang Park, Beomsoo Kim, Hyun Sook Kim, Jihwan Song   +6 more
wiley   +1 more source

The role of dopamine-sensitive motor cortical circuits in the development and execution of skilled forelimb movements. [PDF]

iScience
Gorkowska-Nosal M, Drwiega G, Szumiec L, Rodriguez Parkitna J, Cieslak PE.   +4 more
europepmc   +1 more source

Localised Autophagy Inhibition by Nanodiamonds Potentiates Arsenic Therapy With Favourable Safety Profile in Solid Tumours

Cell Proliferation, EarlyView.
This study presents an NDs‐mediated localised combination strategy that integrates autophagy inhibition with low‐dose ATO sensitization, enabling effective tumour suppression while enhancing safety. NDs‐mediated autophagy blockade enhances ATO efficacy while minimising systemic toxicity, highlighting a promising approach for solid tumour treatment ...
Yiliu Wang, Zhifen Cui, Jichao Zhang, Shitai Zhu, Linjie Guo, Qisheng Wang, Ying Zhu, Shihua Luo, Huating Kong   +8 more
wiley   +1 more source

Full-Fat Rice Bran Ameliorates Insulin Resistance and Modulates Muscle-Related Parameters in High-Fat Diet-Fed Ovariectomized Mice with Potential Involvement of the Gut-Muscle Axis. [PDF]

Nutrients
Loe PY, Ohsaki Y, Yang SC, Shirakawa H, Chiu WC.   +4 more
europepmc   +1 more source

Biomechanical effects of equine training aids: A systematic review

Equine Veterinary Education, EarlyView.
Summary Equine training aids, including auxiliary reins such as draw reins, Pessoa‐type systems and side reins, are widely used during lungeing and ridden exercise to improve posture, back engagement and movement quality. Despite their extensive practical application, the biomechanical effects of these devices remain poorly defined and are often ...
R. F. Siqueira, I. M. Figueiredo
wiley   +1 more source

Transgenic mouse models for investigating human DUX4 expression during development and its roles in FSHD pathophysiology. [PDF]

Dis Model Mech
Hiramuki Y, Himeda CL, Jones PL, Jones TI.   +3 more
europepmc   +1 more source