Results 221 to 230 of about 47,161 (298)

Design, Dynamic Modeling, and Motion Analysis of a Frog-Inspired Hybrid-Driven Amphibious Robot. [PDF]

Sensors (Basel)
Pan Y, Hu L, Ou Y, Fan J.
europepmc   +1 more source

Direct evidence implicating the asymmetrical dimethylarginine (ADMA)‐dimethylarginine dimethylaminohydrolase 1 (DDAH1) pathway in cerebrovascular dysfunction and stroke pathogenesis in mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS), whereas dimethylaminohydrolase 1 (DDAH1) is primarily responsible for its metabolism. However, the roles of DDAH1 in cerebrovascular regulation are poorly understood. Furthermore, despite evidence that elevated ADMA levels are
Arun Flynn, Alexandra Riddell, Ashton Bernard, Jennifer Haggarty, Stefan Weidt, Jawza Alenazi, Erika Trabold, Delyth Graham, Laura B. Dowsett, James Leiper, Alyson A. Miller   +10 more
wiley   +1 more source

Highly aquatic marine stem archosaur with soft tissue preservation. [PDF]

Sci Adv
Wang W, Fraser NC, Spiekman SNF, Li Z, Rieppel O, Lei H, Scheyer TM, Li C.   +7 more
europepmc   +1 more source

Localised Autophagy Inhibition by Nanodiamonds Potentiates Arsenic Therapy With Favourable Safety Profile in Solid Tumours

Cell Proliferation, EarlyView.
This study presents an NDs‐mediated localised combination strategy that integrates autophagy inhibition with low‐dose ATO sensitization, enabling effective tumour suppression while enhancing safety. NDs‐mediated autophagy blockade enhances ATO efficacy while minimising systemic toxicity, highlighting a promising approach for solid tumour treatment ...
Yiliu Wang, Zhifen Cui, Jichao Zhang, Shitai Zhu, Linjie Guo, Qisheng Wang, Ying Zhu, Shihua Luo, Huating Kong   +8 more
wiley   +1 more source

Transcatheter Intra-Arterial Delivery of a Platelet-Derived Extracellular Vesicle-Enriched Preparation for Attenuating Skeletal Muscle Ischaemia-Reperfusion Injury in a Rodent Forelimb Model. [PDF]

J Extracell Vesicles
Selim OA, Sarcon A, Behfar A, Zhao C, Moran SL.   +4 more
europepmc   +1 more source

A Biweekly GLP‐1R Agonist Designed With Drug‐Free Intervals for Enhanced Efficacy, Receptor Homeostasis and Gastrointestinal Tolerability

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding, Qing Liu, Qiong Luo, Xiaojun Yao, Xingxing Fan   +4 more
wiley   +1 more source

Effects of a custom forelimb prosthesis on weight distribution, stability, and gait in a canine amputee: A multi-method approach. [PDF]

Vet Anim Sci
Muršec A, Lampe T, Sodja D, Erjavec V, Fošnarič M.   +4 more
europepmc   +1 more source

Biomechanical effects of equine training aids: A systematic review

Equine Veterinary Education, EarlyView.
Summary Equine training aids, including auxiliary reins such as draw reins, Pessoa‐type systems and side reins, are widely used during lungeing and ridden exercise to improve posture, back engagement and movement quality. Despite their extensive practical application, the biomechanical effects of these devices remain poorly defined and are often ...
R. F. Siqueira, I. M. Figueiredo
wiley   +1 more source

A squirrel-inspired drone with enhanced stability, agility and maneuverability via whole-body morphing. [PDF]

Nat Commun
Zheng L, van Zuijlen A, Hamaza S.
europepmc   +1 more source

Comminuted fractures of the proximal phalanx in horses: A multicentre retrospective review

Equine Veterinary Education, EarlyView.
Summary Background Comminuted fractures of the proximal phalanx (CFPP), defined as the presence of three or more major fracture fragments, present difficult management challenges. Feedback from practitioners and long‐term follow‐up can be helpful to reassess evidence‐based treatment strategies and improve clinical outcomes.
C. de Chaisemartin, M. Farfan, B. Dal Cero, A. Martens, F. Rossignol, A. Kalinovskiy, C. Lischer, C. Tessier, S. Grulke, G. Manneveau, V. Gouzer, G. Gomez, J. Samsel, C. Mespoulhes‐Riviere, F. Pichereau, L. Alfonso Gracia Calvo, M. Trécu, A. Spadaro Rossello, P. Planes, X. Peyrecave, C. Mansuy, C. Henry‐Perin, A. Guezennec, M. C. Schramme   +23 more
wiley   +1 more source