Results 31 to 40 of about 115,571 (268)

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Deoxyribonucleic Acid Extraction Using Iron Oxide Nanoparticle-based Method in Forensic Investigations

Journal of Forensic Science and Medicine
Extraction of deoxyribonucleic acid (DNA) plays a pivotal role in molecular biology, cell biology, genetic research, and forensic inquiries. In the realm of forensic science, the selection of an efficient DNA extraction method holds utmost importance, as
Imran Khan, Gaurav Kaushik
doaj   +1 more source

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Co‐production and adaptation of a prison‐based problem‐solving workbook to support the mental health of patients housed within a medium‐ and low‐secure forensic service

Health Expectations
Introduction Problem‐solving skills (PSS) help to provide a systematic approach to dealing with and managing complex problems. The overall aim of this study was to assess the acceptability and feasibility of developing and adapting a prison‐based PSS ...
Amanda E. Perry, Heather Baker, Anne Aboaja, Lindsey Wilson, Sarah Morris, Patient Public Involved Service User   +5 more
doaj   +1 more source

Molecular techniques for identifying intraguild predators of fishers and other North American small carnivores

Wildlife Society Bulletin, 2013
Identifying predators of threatened and endangered species is important for understanding and reducing the impacts of predation. Visible evidence collected from a carcass alone is often insufficient to accurately identify predator species.
Greta M. Wengert, Mourad W. Gabriel, Janet E. Foley, Teri Kun, Benjamin N. Sacks   +4 more
doaj   +1 more source

Convolutional Neural Network Model for Sex Determination Using Femur Bones

JOIV: International Journal on Informatics Visualization, 2023
Forensic anthropology is the critical discipline that applies physical anthropology in forensic education. One valuable application is the identification of the biological profile. However, in the aftermath of significant disasters, the identification of
Dewi Nasien, M. Hasmil Adiya, Iis Afrianty, Mochammad Farkhan, Rio Juan Hendri Butar-Butar   +4 more
doaj   +1 more source

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Evaluation of forensic psychiatric cases: a four-year review

Psychiatry and Clinical Psychopharmacology, 2021
Objective: This study aims to identify the psychiatric conditions of cases required to be examined psychiatrically, by analyzing retrospectively the forensic reports prepared by the Department of Forensic Medicine of Gulhane Military Medical Academy ...
Huseyin Balandiz, Abdullah Bolu, Harun Tugcu   +2 more
doaj  

Perbandingan antara Pola Sidik Bibir Posisi Normal dengan pada Posisi Bibir Terbuka, Tersenyum dan Mengecup

Journal of Dentistry Indonesia, 2015
Criminal action has shown progressive increase in quality or quantity. To solve criminal cases, important data are needed in identifying individuals. The method of lip print (LP) identification can be applied in certain cases when lip prints can be found
Mindya Juniastuti, Iin Sutisna
doaj   +1 more source

Artificial neural network for gender determination using mandibular morphometric parameters: A comparative retrospective study

Cogent Engineering, 2020
Gender determination is of paramount importance in order to identify the diseased in cases of mass disasters and accidents and to resolve all medico-legal issues in cases of violence.
Vathsala Patil, Ravindranath Vineetha, Saumya Vatsa, Dashrathraj K Shetty, Adithya Raju, Nithesh Naik, Namesh Malarout   +6 more
doaj   +1 more source