Results 131 to 140 of about 198,556 (263)

An Investigation Into the Yields of 3,4‐Methylenedioxyphenyl‐2‐propanone (MDP2P) From Glycidate Pre‐Precursors

open access: yesDrug Testing and Analysis, EarlyView.
Hydrolysis of the glycidate pre‐precursors MMDMG and EMDMG was evaluated for MDP2P production. Acid hydrolysis of MMDMG (HCl, 100°C, 18 h) yielded the highest MDP2P recovery (79%), whereas base hydrolysis produced only slightly lower yields (73%), demonstrating both pathways are effective routes to this key MDMA precursor.
Alexandra L. Mercieca   +4 more
wiley   +1 more source

Population Pharmacokinetics and Detection Times of Betamethasone After Intravenous, Intramuscular, and Intranasal Jet Administration of Betamethasone Sodium Phosphate in Horses

open access: yesDrug Testing and Analysis, EarlyView.
Betamethasone concentrations in 20 horses from Japan and Germany following IV, IM, and INJ administration of betamethasone phosphate were analyzed using population pharmacokinetic modeling. For IV administration of 0.04 mg/kg q24 h, IPC and IUC were 0.012 and 0.31 ng/mL, respectively; the IUC approximated the IFHA urine ISL (0.20 ng/mL).
Taisuke Kuroda   +9 more
wiley   +1 more source

First Occurrence of Fatal Intoxication Involving Methiodone (IC‐26) in Finland; a Medicolegal Autopsy Case Report

open access: yesDrug Testing and Analysis, EarlyView.
ABSTRACT Methiodone (IC‐26) is a non‐fentanyl novel synthetic opioid which has recently been detected in drug seizures in Europe. There is still limited data about the drug in published toxicological case work, both in non‐fatal and fatal cases. We present a medicolegal autopsy case report on a fatal intoxication in an individual undergoing opioid ...
Lasse Pakanen   +2 more
wiley   +1 more source

Supercritical Fluid Chromatography for Expedited Sample Clean‐Up in Isotope Ratio Mass Spectrometry Including Cholesterol as New Endogenous Reference Compound

open access: yesDrug Testing and Analysis, EarlyView.
Supercritical fluid chromatography was employed in the sample preparation for IRMS determinations in sports drug testing for the first time and the developed method was successfully validated. Cholesterol (CHOL) was introduced as a novel endogenous reference compound and population‐based Δ‐values were established as shown here.
Thomas Piper, Jana Drewes, Mario Thevis
wiley   +1 more source

Sleep-Related Eating Disorder and Sexsomnia; Two Rare Parasomnias? A Mini-Review with Illustrative Case-Reports. [PDF]

open access: yesInt J Sex Health
Barcs G   +5 more
europepmc   +1 more source

Impact of Drone Versus Car Transport on Anti‐Doping Sample Integrity Over Short Distances: A Proof‐Of‐Concept Study

open access: yesDrug Testing and Analysis, EarlyView.
This proof‐of‐concept study evaluated the impact of short‐distance drone transport on anti‐doping sample integrity compared with traditional car transport. Targeted assays and untargeted metabolomics revealed equivalent biological profiles between methods, confirming that drone delivery preserves sample integrity for the athlete biological passport ...
I. Al‐Mohannadi   +13 more
wiley   +1 more source

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