Results 51 to 60 of about 4,437,033 (289)

Selective Modulation of OTUB1 Noncanonical Function via a bioPhosTAC Strategy

Advanced Science, EarlyView.
This work positions the versatile performance of the peptide‐based bioPhosTAC platform for dissecting phosphorylation‐dependent biology and expanding the scope of induced‐proximity technologies. We demonstrated that selective manipulation of a tyrosine phosphorylation site is sufficient to propagate coordinated cellular consequences.
Seung Un Seo, Seon Min Woo, Minhyeong Choi, Soeun Rhee, Simmyung Yook, Donghyuk Shin, Kwang‐Su Park, Taeg Kyu Kwon   +7 more
wiley   +1 more source

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

On the Essence of Forensic Expert’s Specialized Knowledge and Feasibility of Its Differentiation

Теория и практика судебной экспертизы
The article presents an analysis of the terms «knowledgeable persons» and «forensic expert». Based on the historical analysis of the activities of the «knowledgeable persons» figure and the «expert» figure, a logical sequence of concepts has been ...
B. M. Bishmanov, G. G. Omel’yanyuk
doaj   +1 more source

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Procedural conflict of appointment and production of Forensic building-technical expertise (FBTE) and methodological approaches for their resolution

MATEC Web of Conferences, 2017
This paper analyzes the procedural conflicts arising from the appointment and manufacture of forensic building-technical expertise and methodical recommendations for their resolution.
Kolobova Svetlana
doaj   +1 more source

Low‐Density Lipoprotein Receptor‐Targeted Biomimetic Nanoplatform Suppresses Glioblastoma Stemness and Remodels Antitumor Immunity via Dual Metabolic Disruption

Advanced Science, EarlyView.
A low‐density lipoprotein receptor‐oriented biomimetic nanoplatform couples brain‐tumor delivery with a mechanistically matched regorafenib‐erythrodiol combination. Concurrent disruption of autophagic nutrient salvage and cholesterol homeostasis collapses bioenergetic and signaling support, suppresses glioblastoma stemness, and promotes immunogenic ...
Yining Jiang, Wenzhuo Yang, Wenting Cheng, Jing Zuo, Lin Pan, Sheng Zhong, Ren Geng, Yao Zhao, Zijian Chen, Canhua Huang, Yang Bai, Liyan Zhao, Yunqian Li   +12 more
wiley   +1 more source

Visualization of nuclear decay activity for forensics and jurisprudence [PDF]

Proceedings of the American Society for Information Science and Technology, 2014
ABSTRACTVisualization can play an important role in the successful prosecution of smugglers of interdicted nuclear materials. Nuclear forensics (the tracing of the source of interdicted materials) is grounded in the science of radioactive decay and those scientific databases which have been developed over the past century on nuclear materials ...
Charles Wang, Ray R. Larson, Electra Sutton, Fredric C. Gey, David Weisz   +4 more
openaire   +1 more source

Diagnosing the system: Mental health, necropolitical uncare, and the abolition of migration detention

American Journal of Community Psychology, EarlyView.
Abstract This article examines the psychological effects of migration detention in the European Union's Closed Controlled Access Center (CCAC) on Samos through an ecological lens. It explores a double normalization of suffering: the brutalization of necropolitical migration governance and the simultaneous understanding of resulting distress as an ...
Julia Manek
wiley   +1 more source

Forensic Science and Forensic Expert Activity: a View Through the Prism of Forensic Experts’ Opinions

Theory and Practice of Forensic Science and Criminalistics, 2023
The primary concerns of this paper are to study the phenomenon of forensic science and determine ways of optimizing forensic expert practice in Ukraine by summarizing opinions of forensic experts. Based on the survey conducted among forensic experts, issues of legal regulation of forensic science have been considered; the need to unify provisions ...
openaire   +1 more source

Helping with inquiries: theory and practice in forensic science [PDF]

, 2009
This thesis investigates the reasoning practices of forensic scientists, with specific focus on the application of the Bayesian form of probabilistic reasoning to forensic science matters.
Lawless, Christopher James
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