Results 41 to 50 of about 17,450 (256)
Advanced Science, EarlyView.A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu +17 more
wiley +1 more source
VIRTual autOPSY—applying CT and MRI for modern forensic death investigations
Frontiers in RadiologyVirtual autopsy, an advanced forensic technique, utilizes cutting-edge imaging technologies such as computed tomography (CT) and magnetic resonance imaging (MRI) to investigate the cause and manner of death without the need for physical dissection.
Dominic Gascho
doaj +1 more source
Advanced Science, EarlyView.Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong +12 more
wiley +1 more source
Journal of Forensic Science and MedicineVirtual autopsy, or virtopsy, is an innovative forensic technique that employs advanced imaging modalities such as computed tomography and magnetic resonance imaging for the examination of cadavers. Compared to the standard autopsy, an invasive procedure,
Kiran R. Dodiya +3 more
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Advanced Science, EarlyView.Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang +19 more
wiley +1 more source
Using 3D CNN for classification of Parkinson’s disease from resting-state fMRI data
Journal of Engineering and Applied Science, 2023 Parkinson’s disease is a chronic and progressive movement disorder caused by the degeneration of dopamine-producing neurons in the substantia nigra of the brain.
Nair Ul Islam +2 more
doaj +1 more source
Advanced Science, EarlyView.Chronic stress disrupts copper homeostasis and promotes copper accumulation in the prelimbic cortex, leading to astrocytic FDX1 upregulation. Elevated astrocytic FDX1 impairs calcium signaling, induces structural atrophy, and disrupts synaptic function, contributing to depressive‐like behaviors. Physical exercise reverses these alterations by restoring
Lina Gao +11 more
wiley +1 more source
Ruler Detection for Autoscaling Forensic Images [PDF]
International Journal of Digital Crime and Forensics, 2014 The assessment of forensic photographs often requires the calibration of the resolution of the image so that accurate measurements can be taken of crime-scene exhibits or latent marks. In the case of latent marks, such as fingerprints, image calibration to a given dots-per-inch is a necessary step for image segmentation, preprocessing, extraction of ...
Abhir Bhalerao, Gregory Reynolds
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Advanced Science, EarlyView.Lanthanide‐doped polyurea microspheres are prepared via a facile one‐step precipitation polymerization. They exhibit strong hydrogen‐bonding and coordination interactions with excellent properties, including multicolor emission, high quantum yield (75.3%), remarkable stability, redispersibility, and biocompatibility.
Guiyu Zhang +9 more
wiley +1 more source
Advanced Science, EarlyView.Therapeutic role and mechanism of human urine stem cells (hUSCs) in pulmonary fibrosis. hUSCs alleviated pulmonary fibrosis by selectively inhibiting macrophage‐myofibroblast transition (MMT) in two ways: on one hand, hUSCs inhibited mitochondrial reactive oxygen species (mtROS) production and apoptosis/senescence of epithelial cells in pulmonary ...
Zhou‐Hang Zhang +10 more
wiley +1 more source