Results 41 to 50 of about 2,922,640 (249)

Selective Modulation of OTUB1 Noncanonical Function via a bioPhosTAC Strategy

Advanced Science, EarlyView.
This work positions the versatile performance of the peptide‐based bioPhosTAC platform for dissecting phosphorylation‐dependent biology and expanding the scope of induced‐proximity technologies. We demonstrated that selective manipulation of a tyrosine phosphorylation site is sufficient to propagate coordinated cellular consequences.
Seung Un Seo, Seon Min Woo, Minhyeong Choi, Soeun Rhee, Simmyung Yook, Donghyuk Shin, Kwang‐Su Park, Taeg Kyu Kwon   +7 more
wiley   +1 more source

The foot in forensic human identification - a review [PDF]

, 2014
The identification of human remains is a process which can be attempted irrespective of the stage of decomposition in which the remains are found or the anatomical regions recovered. In recent years, the discovery of fragmented human remains has garnered
Hackman, L., Hackman, L.; id_orcid, Black, S. M., Davies, Catriona, Black, Sue   +4 more
core   +1 more source

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

The First Arab Forensic Sciences & Forensic Medicine Meeting 2014: Meeting Report

Arab Journal of Forensic Sciences & Forensic Medicine, 2015
The First Arab Forensic Science & Forensic MedicineMeeting 2014 was held in Riyadh (October 26-28, 2014)at Naif Arab University for Security Sciences (NAUSS),Riyadh, Kingdom of Saudi Arabia.
Abdulsallam Bakdash, Mohammad bin Ali Al Saad, Abdulwali Mohamed Said Ajlouni, Abdul Rauf Chaudhary   +3 more
doaj   +1 more source

Palaeoproteomic Deconvolution of Physical and Genetic Collagen Mixtures

Advanced Science, EarlyView.
ClassiCOL_v2 uses a novel “peptide patching” framework that treats any collagen sample as a patchwork of peptide sequences derived from phylogenetically related species. This allows the algorithm to simultaneously resolve two previously intractable problems: multi‐species samples and/or database deficiencies.
Ian Engels, Tristan Dedrie, Synnøve K. Mo, Simon Van de Vyver, Thijs R. A. Vandenbroucke, Kévin Di Modíca, Jan Decher, Alice Toso, Dieter Deforce, Simon Daled, Alexandra Burnett, Grégory Abrams, Maarten Dhaenens   +12 more
wiley   +1 more source

Creation and Exploration of the “Organized Fill-in-the-Blank Format” Discipline Construction Model for Forensic Medicine in the New Era

Fayixue Zazhi
Forensic medicine has been designated as a first-level discipline, presenting new opportunities and challenges for the development of forensic medicine. Since the 1980s, the establishment of forensic medicine discipline and the cultivation of high-level ...
WEI Zhi-wen, WANG Hong-xing, SUN Jun-hong, FAN Hao-liang, SU Hong-liang, WANG Le-le, HE Wen-ting, CHEN Zhe, ZHANG Jie, GUO Xiang-jie, LI Ji, ZHANG Geng-qian, LIANG Xin-hua, YAN Jiang-wei, ZHANG Qiang-qiang, GAO Cai-rong, WANG Ying-yuan, WANG Hong-wei, XIE Jun, ZHU Bo-feng, YUN Ke-ming   +20 more
doaj   +1 more source

Area of specialty preferences of forensic authorities in forensic psychiatric evaluation requests: a university hospital experience [PDF]

Düşünen Adam Psikiyatri ve Nörolojik Bilimler Dergisi, 2014
Objective: In this study, we aimed to find the relevant factors of forensic medicine, child and adolescent psychiatry, and psychiatry fields’ preferences in the forensic psychiatric assessment requests of forensic authorities. Method: Case records which
mustafa talip sener, onur burak dursun, esat fahri aydin, semiha arslan, mustafa gulec   +4 more
doaj  

Diagnosing the system: Mental health, necropolitical uncare, and the abolition of migration detention

American Journal of Community Psychology, EarlyView.
Abstract This article examines the psychological effects of migration detention in the European Union's Closed Controlled Access Center (CCAC) on Samos through an ecological lens. It explores a double normalization of suffering: the brutalization of necropolitical migration governance and the simultaneous understanding of resulting distress as an ...
Julia Manek
wiley   +1 more source

Measuring Child Disadvantage: Comparing Multidimensional and Socioeconomic Approaches for Predicting Developmental Outcomes

Australian Journal of Social Issues, EarlyView.
ABSTRACT Robust measurement of disadvantage is essential to identifying and addressing inequities in children's development. We tested how a multidimensional framework of child disadvantage performed relative to a traditional socioeconomic position (SEP) approach to predict developmental outcomes.
Wei Hong, Fiona Mensah, Elodie O'Connor, Shuaijun Guo, Sharon Goldfeld, Meredith O'Connor, Cindy Pham, Sarah Gray   +7 more
wiley   +1 more source