Results 11 to 20 of about 41,539 (216)

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

open access: yesAdvanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong   +12 more
wiley   +1 more source

Enhancing Biogenic Formic Acid Production in the Modified OxFA Process by Acetonitrile Addition

open access: yesAdvanced Science, EarlyView.
In this study, the beneficial effect of using acetonitrile as a co‐solvent in the modified OxFA process is shown, outperforming methanol, demonstrating improved reaction kinetics combined with high selectivity for the HPA‐2 (H5PV2Mo10O40) catalyzed oxidation of xylose to FA.
Jan‐Dominik H. Krueger   +7 more
wiley   +1 more source

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

open access: yesAdvanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang   +19 more
wiley   +1 more source

Introduction to Forensic Science [PDF]

open access: yesAmerican Society for Clinical Laboratory Science, 2012
1. Donald C. Lehman, EdD, MT(ASCP), SM(NRM)[⇑][1] 1. University of Delaware, Newark, DE 19716 1. Address for Correspondence: Donald C. Lehman, EdD, MT(ASCP), SM(NRM), Department of Med-ical Technology. University of Delaware, Newark, DE 19716, (302) 831-8432, dlehman{at}udel.edu 1. Discuss the role of forensic scientists. 2.
openaire   +2 more sources

Measuring Uncertainty in Forensic Science

open access: yesIEEE Instrumentation & Measurement Magazine, 2021
This paper aims at describing the ways in which uncertainty is (or is not) measured in the field of forensic science and how the measure of uncertainty can be used to make better judicial decisions. From the traditional fingerprint comparison to the latest advances in forensic DNA analysis, we discuss the advantages and drawbacks of various ways of ...
Vuille, Joelle, Taroni, Franco
openaire   +2 more sources

Astrocytic FDX1 Contributes to Copper Dyshomeostasis‐associated Synaptic Dysfunction in Depression and Is Modulated by Exercise

open access: yesAdvanced Science, EarlyView.
Chronic stress disrupts copper homeostasis and promotes copper accumulation in the prelimbic cortex, leading to astrocytic FDX1 upregulation. Elevated astrocytic FDX1 impairs calcium signaling, induces structural atrophy, and disrupts synaptic function, contributing to depressive‐like behaviors. Physical exercise reverses these alterations by restoring
Lina Gao   +11 more
wiley   +1 more source

Forensic Science: Oxymoron? [PDF]

open access: yesScience, 2003
I n detective novels and television series, criminals often get caught because they leave fingerprints at the scene. Well, art does imitate life; fingerprint analysis is widely used in U.S. courts and those of many other countries. But last year a funny thing happened to fingerprint evidence on the way to a conviction. Applying the standard set for the
openaire   +2 more sources

One‐Step Preparation of Lanthanide‐Doped Polyurea Multicolor Microspheres for Versatile Fluorescent Applications

open access: yesAdvanced Science, EarlyView.
Lanthanide‐doped polyurea microspheres are prepared via a facile one‐step precipitation polymerization. They exhibit strong hydrogen‐bonding and coordination interactions with excellent properties, including multicolor emission, high quantum yield (75.3%), remarkable stability, redispersibility, and biocompatibility.
Guiyu Zhang   +9 more
wiley   +1 more source

A call for more science in forensic science [PDF]

open access: yesProceedings of the National Academy of Sciences, 2018
Forensic science is critical to the administration of justice. The discipline of forensic science is remarkably complex and includes methodologies ranging from DNA analysis to chemical composition to pattern recognition. Many forensic practices developed under the auspices of law enforcement and were vetted primarily by the legal system rather than ...
Suzanne Bell   +5 more
openaire   +2 more sources

Human Urine Stem Cells Alleviate Pulmonary Fibrosis via Inhibiting Macrophage‐Myofibroblast Transition

open access: yesAdvanced Science, EarlyView.
Therapeutic role and mechanism of human urine stem cells (hUSCs) in pulmonary fibrosis. hUSCs alleviated pulmonary fibrosis by selectively inhibiting macrophage‐myofibroblast transition (MMT) in two ways: on one hand, hUSCs inhibited mitochondrial reactive oxygen species (mtROS) production and apoptosis/senescence of epithelial cells in pulmonary ...
Zhou‐Hang Zhang   +10 more
wiley   +1 more source

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