Results 171 to 180 of about 380,766 (261)

In vitro activation of the CB1 receptor by the semi‐synthetic cannabinoids hexahydrocannabinol (HHC), hexahydrocannabinol acetate (HHC‐O) and hexahydrocannabiphorol (HHC‐P)

Drug Testing and Analysis, EarlyView.
The semi‐synthetic cannabinoids market is developing rapidly, and 24 European countries have identified HHC, often sold openly. This study characterized the in vitro activation of the human CB1 receptor by the (9R) and (9S) epimers of HHC, HHC‐P and HHC‐O.
Mattias Persson, Robert Kronstrand, Michael Evans‐Brown, Henrik Green   +3 more
wiley   +1 more source

Detection of transgenes in equine dried blood spots using digital PCR and qPCR for gene doping control

Drug Testing and Analysis, EarlyView.
DNA extraction methods for dried blood spots (DBS) were evaluated to determine the suitability of the use of DBS as an alternative matrix for transgene detection towards gene doping screening. DNA was quantified using two detection methods: qPCR and dPCR.
Jillian Maniego, Caitlin Harding, Jocelyn Habershon‐Butcher, Pamela Hincks, Graham Stewart, Christopher Proudman, Edward Ryder   +6 more
wiley   +1 more source

Isolation and characterization of synthesis intermediates and side products in hexahydrocannabiphorol

Drug Testing and Analysis, EarlyView.
A commercially purchased hexahydrocannabiphorol (HHCP) sample for recreational use was analyzed by GC‐MS. In addition to the declared (9R)‐ and (9S)‐HHCP, the chromatogram showed a large number of isomeric compounds and other impurities, six of which, including (9R)‐HHCP, were isolated and their structure elucidated using various NMR techniques and GC ...
Willi Schirmer, Ilche Gjuroski, Martina Vermathen, Julien Furrer, Stefan Schürch, Wolfgang Weinmann   +5 more
wiley   +1 more source

The analysis of methylamphetamine and para‐hydroxy‐methylamphetamine in post‐mortem hair samples using liquid chromatography–tandem mass spectrometry

Drug Testing and Analysis, EarlyView.
We present an analytical method for the determination of methylamphetamine (MA), amphetamine, and para‐hydroxy‐methylamphetamine (p‐OH‐MA) in hair. Concentrations of p‐OH‐MA were 0.0012–0.38 ng/mg (median = 0.020) among 62 deceased persons, although wash/hair ratios were indicative of external contamination.
Dylan Mantinieks, Olaf H. Drummer, Jennifer Schumann, Dimitri Gerostamoulos   +3 more
wiley   +1 more source

Detection of the GH analog somatrogon in sports drug testing: Immunological approaches and LC‐HRMS/MS

Drug Testing and Analysis, EarlyView.
The detectability of the GH analog somatrogon with approved doping control immunoassays for hGH and hCG was evaluated and a both sensitive and specific qualitative detection assay employing affinity purification, tryptic digestion, and LC‐HRMS/MS was developed to confirm the presence of the drug in suspicious serum samples. Abstract Due to the presumed
Katja Walpurgis, Andreas Thomas, Mitsuhiko Sato, Masato Okano, Hans Geyer, Mario Thevis   +5 more
wiley   +1 more source

Analytical and behavioral characterization of 1‐hexanoyl‐LSD (1H‐LSD)

Drug Testing and Analysis, EarlyView.
Analytical and pharmacological data were obtained from 1‐hexanoyl‐LSD (1H‐LSD). The mouse head‐twitch response revealed that 1H‐LSD induced LSD‐like effects (ED50 = 387 nmol/kg). The behavioral and analytical characterization of novel lysergamides aim to extend the understanding of structure–activity relationships and disseminate data for those ...
Simon D. Brandt, Pierce V. Kavanagh, Sarah Gare, Alexander Stratford, Adam L. Halberstadt   +4 more
wiley   +1 more source

Simultaneous detection of three hypoxia‐inducible factor stabilizers—molidustat, roxadustat, and vadadustat—in multiple keratinized matrices and its application in a doping context

Drug Testing and Analysis, EarlyView.
The authors present a method for the simultaneous identification and quantification of three HIF stabilizers in multiple keratinized matrices, with the first identification of molidustat in hair, beard hair and fingernails in an authentic doping case.
Anne Checkouri, Laurie Gheddar, Nadia Arbouche, Jean‐Sébastien Raul, Pascal Kintz   +4 more
wiley   +1 more source

In vitro metabolism study of ADB‐P‐5Br‐INACA and ADB‐4en‐P‐5Br‐INACA using human hepatocytes, liver microsomes, and in‐house synthesized references

Drug Testing and Analysis, EarlyView.
Analyzing hepatocytes and liver microsomes samples along with synthesized references. Complete structure elucidation of major metabolites was possible, and biomarkers for both ADB‐P‐5Br‐INACA and ADB‐4en‐P‐5Br‐INACA were suggested. Abstract Synthetic cannabinoids (SCs) remain a major public health concern, as they continuously are linked to severe ...
Tobias Rautio, Robin Obrist, Lucas Krebs, Therése Klingstedt, Johan Dahlén, Xiongyu Wu, Henrik Gréen   +6 more
wiley   +1 more source

Pharmacogenetics Role in Forensic Sciences [PDF]

, 2011
Buscemi, Loredana, Tagliabracci, Adriano
core   +1 more source

Forensic Sciences

Journal of AOAC INTERNATIONAL, 1989
openaire   +1 more source