Results 181 to 190 of about 380,766 (261)

Interest of hair tests to discriminate a tail end of a doping regimen from a possible contamination in case of challenging an anti‐doping rule violation. V. Case reports involving trimetazidine, a drug where the concentration after a single 20 mg dose has been established

Drug Testing and Analysis, EarlyView.
From ingestion to hair incorporation Abstract The identification of trimetazidine, a medicine used for treating stable angina pectoris and for preventing angina attacks, has been recently observed in doping cases involving high profile athletes from various countries over the world.
Pascal Kintz, Alice Ameline, Laurie Gheddar   +2 more
wiley   +1 more source

Mercaptans in malodorants break disulfide bridges in human serum albumin and form adducts suitable as biomarkers of exposure in vitro

Drug Testing and Analysis, EarlyView.
Disulfide adducts of mercaptans with cysteine residues in human serum albumin were detected as tripeptides and dipeptides after proteolysis with proteinase K. All peptide adducts were detected simultaneously with a mass spectrometry‐based method working in the scheduled multiple reaction monitoring (sMRM) mode.
Paula Helena Sieber, Dirk Steinritz, Franz Worek, Harald John   +3 more
wiley   +1 more source

High‐throughput liquid chromatography‐vacuum differential mobility spectrometry‐mass spectrometry for the analysis of isomeric drugs of abuse in human urine

Drug Testing and Analysis, EarlyView.
This report describes the potential of vacuum differential mobility spectrometry (DMS) as an additional separation dimension to reduce liquid chromatography (LC‐MS) analysis time while maintaining good quantitative performance. A 1‐min trap/elute LC‐vDMS‐SIM/MS method for quantification of 11 drugs of abuse was developed and applied to the analysis of ...
Maria Fernanda Cifuentes Girard, Patrick Knight, Gérard Hopfgartner   +2 more
wiley   +1 more source

Report on Forensic Science

Journal of AOAC INTERNATIONAL, 1972
openaire   +4 more sources

Quantitative analysis of nonsteroidal anti‐inflammatory drugs in dried blood spot from mountain ultra‐trail runners. Contribution of pharmacokinetic models for the interpretation of the results

Drug Testing and Analysis, EarlyView.
Quantification of 16 nonsteroidal anti‐inflammatory drugs using dried blood spot and LC–MS/HRMS was performed. By using a pharmacokinetic modelling and simulations, and according to the analytical performances of the method, detection windows for ibuprofen in ultra‐trail runners were proposed.
Mohammad Shafiq Mashal, Jérôme Guitton, Pierre Sallet, Laurent Bourguignon, Christelle Machon   +4 more
wiley   +1 more source

Metabolism study of 3‐chloromethcathinone (3‐CMC) by dried blood spot (DBS) sampling after controlled administration using a murine model

Drug Testing and Analysis, EarlyView.
The metabolism of 3‐chloromethcathinone (3‐CMC) was studied after controlled administration in a murine model using the dried blood spot (DBS) technique for the sampling, storage and purification of blood samples. The metabolite profile of 3‐CMC was studied by LC‐HRMS, while the stability of 3‐CMC and its three identified metabolites was also assessed ...
Serena Mestria, Sara Odoardi, Valeria Valentini, Giorgia Corli, Marta Bassi, Matteo Marti, Sabina Strano‐Rossi   +6 more
wiley   +1 more source

Interlaboratory comparison of phosphatidylethanol in dried blood spots using different sampling devices

Drug Testing and Analysis, EarlyView.
In this article, we present the results of three rounds of interlaboratory comparison conducted in 2022 and 2023 for phosphatidylethanol (PEth) in authentic fresh blood samples using different types of microsampling devices. More than 20 laboratories from Europe and the US participated, and 73% quantified and reported all 12 samples covering a range ...
Matthias Bantle, Frederike Stöth, Wolfgang Weinmann, Marc Luginbühl   +3 more
wiley   +1 more source

Identification of human metabolites of fast skeletal troponin activators Tirasemtiv and Reldesemtiv for doping control purposes

Drug Testing and Analysis, EarlyView.
The metabolism and urinary elimination of two substances recently classified as prohibited substances in sport was conducted, yielding suitable target analytes for efficient doping controls employing routinely applied chromatographic‐mass spectrometric test methods.
Luisa Euler, Kim Deinert, Felicitas Wagener, Katja Walpurgis, Mario Thevis   +4 more
wiley   +1 more source

Beta2‐adrenergic agonist salbutamol exhibits enantioselective disposition in skeletal muscle of lean young men following oral administration

Drug Testing and Analysis, EarlyView.
Oral administration of salbutamol shows enantioselective disposition in human skeletal muscle, favoring the (S)‐enantiomer with higher relative partitioning of the pharmacologically active (R)‐enantiomer in muscle. This is concerning from an anti‐doping point of view because the anabolic properties demonstrated for salbutamol can potentially be ...
Morten Hostrup, Glenn A. Jacobson, Kasper Eibye, Christian K. Narkowicz, David S. Nichols, Søren Jessen   +5 more
wiley   +1 more source

Changing trends in anabolic‐androgenic steroid use within Scottish prisons: Detection, prevalence, and quantitation

Drug Testing and Analysis, EarlyView.
This study reports the qualitative and quantitative detection of anabolic‐androgenic steroids (AASs) in seized samples from prisons. Since 2022 there has been an increase in AAS detections with oxymetholone the most prevalent AAS, followed by metandienone, methyltestosterone, and oxandrolone.
Caitlyn Norman, Richard L. Harries, Robert Reid, Lorna A. Nisbet, Niamh Nic Daéid   +4 more
wiley   +1 more source