Results 41 to 50 of about 54,598 (260)

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

open access: yesAdvanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu   +7 more
wiley   +1 more source

Enhancing the Scientific Validity of Methodological Support in Forensic Science: An Important International Trend

open access: yesТеория и практика судебной экспертизы, 2017
One of the key requirements of modern-day forensic practice is to enforce the principle of scientific validity of applied methods. Current practices show that the issues of scientific validity of forensic methodologies and methodological validation of ...
Svetlana A. Smirnova, Aleksandr I. Usov
doaj   +1 more source

Measuring Uncertainty in Forensic Science

open access: yesIEEE Instrumentation & Measurement Magazine, 2021
This paper aims at describing the ways in which uncertainty is (or is not) measured in the field of forensic science and how the measure of uncertainty can be used to make better judicial decisions. From the traditional fingerprint comparison to the latest advances in forensic DNA analysis, we discuss the advantages and drawbacks of various ways of ...
Vuille, Joelle, Taroni, Franco
openaire   +2 more sources

Palaeoproteomic Deconvolution of Physical and Genetic Collagen Mixtures

open access: yesAdvanced Science, EarlyView.
ClassiCOL_v2 uses a novel “peptide patching” framework that treats any collagen sample as a patchwork of peptide sequences derived from phylogenetically related species. This allows the algorithm to simultaneously resolve two previously intractable problems: multi‐species samples and/or database deficiencies.
Ian Engels   +12 more
wiley   +1 more source

New Publications in Forensic Science

open access: yesТеория и практика судебной экспертизы, 2023
This section presents translated abstracts of selected papers that appeared in the following periodicals: Forensic Science International [www.elsevier.com/locate/forsciint], Forensic Science International: Digital Investigation [www.elsevier.com/locate ...
N. V. Fetisenkova, D. V. Zav’yalova
doaj  

Low‐Density Lipoprotein Receptor‐Targeted Biomimetic Nanoplatform Suppresses Glioblastoma Stemness and Remodels Antitumor Immunity via Dual Metabolic Disruption

open access: yesAdvanced Science, EarlyView.
A low‐density lipoprotein receptor‐oriented biomimetic nanoplatform couples brain‐tumor delivery with a mechanistically matched regorafenib‐erythrodiol combination. Concurrent disruption of autophagic nutrient salvage and cholesterol homeostasis collapses bioenergetic and signaling support, suppresses glioblastoma stemness, and promotes immunogenic ...
Yining Jiang   +12 more
wiley   +1 more source

Significance of Dental Records in Personal Identification in Forensic Sciences

open access: yesJournal of Forensic Science and Medicine, 2016
Forensic odontology is a branch that connects dentistry and the legal profession. One of the members in the forensic investigation team is a dentist. Dentists play an important and significant role in various aspects of the identification of persons in ...
Vagish Kumar L Shanbhag
doaj   +1 more source

Diagnosing the system: Mental health, necropolitical uncare, and the abolition of migration detention

open access: yesAmerican Journal of Community Psychology, EarlyView.
Abstract This article examines the psychological effects of migration detention in the European Union's Closed Controlled Access Center (CCAC) on Samos through an ecological lens. It explores a double normalization of suffering: the brutalization of necropolitical migration governance and the simultaneous understanding of resulting distress as an ...
Julia Manek
wiley   +1 more source

Measuring Child Disadvantage: Comparing Multidimensional and Socioeconomic Approaches for Predicting Developmental Outcomes

open access: yesAustralian Journal of Social Issues, EarlyView.
ABSTRACT Robust measurement of disadvantage is essential to identifying and addressing inequities in children's development. We tested how a multidimensional framework of child disadvantage performed relative to a traditional socioeconomic position (SEP) approach to predict developmental outcomes.
Wei Hong   +7 more
wiley   +1 more source

Influence and challenge of COVID-19 in forensic identification

open access: yesJournal of Forensic Science and Medicine, 2020
During the COVID-19 epidemic, the professionals in the field of forensic pathology, forensic sciences in general, and clinical forensic medicine have been performing medicolegal investigation in their communities. The forensic medical personnel who carry
Bin Cong, Xin Liu
doaj   +1 more source

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