Results 191 to 200 of about 22,242 (266)

Ion Activation Methods for Top‐Down Proteomics

open access: yesMass Spectrometry Reviews, EarlyView.
ABSTRACT Mass spectrometry (MS) has emerged as a premier method used to characterize the sequences of proteins. Top‐down proteomics aims to capture the multiple sources of structural diversity reflected in proteins, such as those that arise from alternative RNA splicing events or the addition of post‐translational modifications. Tandem MS (i.e., MS/MS)
Jada N. Walker, Jennifer S. Brodbelt
wiley   +1 more source

First 20 Years of Orbitrap Mass Spectrometry as the Mainstream Analytical Technique

open access: yesMass Spectrometry Reviews, EarlyView.
ABSTRACT This review traces the first 20 years of Orbitrap mass spectrometry as a mainstream high‑resolution and accurate‑mass (HR/AM) technology. It outlines the historical development of the Orbitrap analyzer, the evolution of major instrument families, and the key technological innovations that enabled its widespread adoption. Particular emphasis is
Alexander Makarov
wiley   +1 more source

Terminology, retrieval bias, and field definition in forensic genetic genealogy. [PDF]

open access: yesForensic Sci Int Synerg
Mittelman D, Budowle B, Mittelman K.
europepmc   +1 more source

Recent Advances (2023–2025) of Capillary Electrophoresis‐Mass Spectrometry (CE‐MS) for Top‐Down Proteomics

open access: yesMass Spectrometry Reviews, EarlyView.
ABSTRACT Top‐down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform detection, given the extremely high proteoform complexity and wide proteoform concentration dynamic range.
Guijie Zhu   +5 more
wiley   +1 more source

Interpol review of forensic toxicology, 2023-2025. [PDF]

open access: yesForensic Sci Int Synerg
Ip SC   +12 more
europepmc   +1 more source

Recent Advances in Top‐Down Proteomics for Single‐Cell Research

open access: yesMass Spectrometry Reviews, EarlyView.
ABSTRACT Individual cells have distinctive molecular characteristics, including biologically relevant proteoforms. Although single‐cell (SC) molecular omics offer unprecedented insights into cellular heterogeneity and function, the characterization of proteoforms in SCs remains an uncharted territory.
Jake A. Melby, Pei Su, Fabio P. Gomes
wiley   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

open access: yesMass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág   +5 more
wiley   +1 more source

Synthesis of Borneol‐Polymers as Fluorescent Sensors for Pollutant Detection

open access: yesMacromolecular Symposia, EarlyView.
ABSTRACT In this work, a borneol‐derived monomer was employed to synthesize two novel copolymers, poly(vinyl acetate‐co‐bornyl methacrylate) (CopBM‐1) and poly(p‐acryloyloxybenzaldehyde‐co‐bornyl methacrylate) (CopBM‐2), via radical copolymerization. Both copolymers demonstrated aggregation‐induced emission in DMF at concentrations exceeding 0.04 wt.%.
Viorica‐Elena Podasca   +2 more
wiley   +1 more source

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