Results 31 to 40 of about 32,876 (263)

Climatic and socioeconomic conditions jointly drive the carbon emissions of the urban passenger transport sector

Humanities & Social Sciences Communications
Because of the dramatic rise in vehicle holdings, 21% of global energy consumption and nearly a quarter of carbon emissions now come from the transportation sector.
Siyan Chen, Haiyan Duan, Junhua Song, Zhiyuan Duan, Bailin He, Zhenhui Gao, Lixiao Zhang   +6 more
doaj   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Subtype‐associated complexity and prognostic significance of the NLRP3 inflammasome landscape in pancreatic neoplasms

The Journal of Pathology: Clinical Research
Intraductal papillary mucinous neoplasm (IPMN) can progress into malignant pancreatic cancer, posing challenges in accurately assessing the risk of malignancy.
Kristóf Németh, Eszter Mezei, Justína Vörös, Katalin Borka, Adrián Pesti, István Kenessey, András Kiss, András Budai   +7 more
doaj   +1 more source

Myth debunked: Keratinous pangolin scales do not contain the analgesic tramadol

Conservation Science and Practice, 2019
Conservation plans aiming to reduce the threat of illegal wildlife trade increasingly recognize the need for multifaceted approaches that include both enhanced enforcement and demand reduction initiatives.
Rachel L. Jacobs, Pamela J. McClure, Barry W. Baker, Edgard O. Espinoza   +3 more
doaj   +1 more source

Incident Analysis & Digital Forensics in SCADA and Industrial Control Systems

, 2013
SCADA and industrial control systems have been traditionally isolated in physically protected environments. However, developments such as standardisation of data exchange protocols and increased use of IP, emerging wireless sensor networks and machine-to-
May, John H R, J. May, Spyridopoulos, Theodoros, Tryfonas, Theo, T. Tryfonas, T. Spyridopoulos, May, J.   +6 more
core   +1 more source

Digital forensic readiness : an insight into governmental and academic initiatives [PDF]

, 2011
Digital forensics is a discipline that primarily focuses on the post-incident side of an investigation. However, during the last decade, there is a considerable amount of research that considers proactive measures taken by an organization.
Marthie Grobler, Grobler, Marthie, Chang-Tsun Li, Mouhtaropoulos, Antonis, Antonis Mouhtaropoulos, Li, Chang-Tsun   +5 more
core   +1 more source

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

Comparison of Two Massively Parallel Sequencing Platforms using 83 Single Nucleotide Polymorphisms for Human Identification

Scientific Reports, 2017
The potential of Massively Parallel Sequencing (MPS) technology to vastly expand the capabilities of human identification led to the emergence of different MPS platforms that use forensically relevant genetic markers.
Dame Loveliness T. Apaga, Sheila E. Dennis, Jazelyn M. Salvador, Gayvelline C. Calacal, Maria Corazon A. De Ungria   +4 more
doaj   +1 more source

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Novel method of ecological damage assessment for intentional destruction of cultural relics and historic sites

Cogent Social Sciences
Recent years have witnessed a spurt of progress in China’s tourism industry, contributing greatly to the economy, culture, and ecology. Cultural relics and historic sites boast significant value in terms of tourism, economic, ecological service, cultural,
Jianing Lin, Leping Zhang, Ningjie Li, Zhiguo Zhang, Bairui Lu, Lihui Huang, Ao Li, Meng Gao, Jinhui Wang, Zhenhui Gao, Ting Sun   +10 more
doaj   +1 more source