Results 121 to 130 of about 44,821 (231)

Ventilator‐Induced Lung Injury: Mechanotransduction and Potential Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Mechanical ventilation (MV) is expected to undergo significant transformative advancements by 2050, with the emergence of personalized ventilation systems that promise to revolutionize respiratory care. However, the risk of ventilator‐induced lung injury (VILI) remains a significant concern at this stage and VILI still exists at that time.
He Ren, Ziqi Shang, Alastair G. Stewart, Ying‐xin Qi, Kai Huang   +4 more
wiley   +1 more source

Impact of antimicrobials on penile HIV susceptibility and immunology in uncircumcised men: A randomized phase 1/2 clinical trial

Cell Reports Medicine
Summary: Within the penile microbiome, bacteria associated with seroconversion, immunology, and cells (BASIC species) enhance HIV susceptibility in heterosexual uncircumcised men by inducing foreskin inflammation and HIV target cell recruitment.
Ronald M. Galiwango, Brenda Okech, Daniel E. Park, Lane Buchanan, Zhongtian Shao, Bernard Bagaya, Juliet Mpendo, Vineet Joag, Sergey Yegorov, Annet Nanvubya, Victoria M. Biribawa, Teddy Namatovu, Charles Kato, Barbara Kawoozo, Ali Ssetaala, Moses Muwanga, Maliha Aziz, Tony Pham, Sanja Huibner, Aaron A.R. Tobian, Cindy M. Liu, Jessica L. Prodger, Rupert Kaul   +22 more
doaj   +1 more source

Chemical dehydration‐induced ultrafast clearing method for human tissues

VIEW, Volume 7, Issue 1, February 2026.
Three‐dimensional (3D) histology of human tissue through clearing has been hampered by the lengthy and intricate procedure. Here, a rapid and straightforward clearing protocol termed single‐step dehydration solvent‐based clearing (SSD) is proposed via a chemical dehydration strategy.
Yi Dai, Jianyi Xu, Jie Hao, Zhang Liu, Chengze Lan, Guanghua Xu, Xizhi Meng, Yating Deng, Peng Wan, Kunxing Liu, Yingtao Yao, Fang Zhao, Peng Fei, Xiu Nie, Gang Lv, Dan Zhu, Tingting Yu   +16 more
wiley   +1 more source

Non‐resectable extratesticular sustentacular cell tumour treated with palliative‐intent radiation and carboplatin chemotherapy in a dog

Veterinary Record Case Reports, Volume 14, Issue 1, February 2026.
Abstract There is limited published information regarding the diagnosis and treatment of sustentacular cell neoplasia in dogs, and no data evaluating the use of radiation and chemotherapy for those tumours that are non‐resectable. This case report describes a 5‐year‐old, male, neutered German shepherd dog presented with a large, rapidly growing ...
Kathryn J. Jensen, Dah‐Renn Fu, Christopher Premanandan, Rhonda Burge   +3 more
wiley   +1 more source

Preliminary study of a new magnetic compression technique for circumcision in dogs: An experimental animal model

Heliyon
Introduction: Traditional/ritual/medical circumcision can be associated with considerable intraoperative blood loss and a prolonged postoperative healing course.
Miaomiao Zhang, Linxin Shen, Kaihua Xue, Aihua Shi, Yanfeng Gao, Yi Lyu, Xiaopeng Yan   +6 more
doaj   +1 more source

Transdermal Delivery of Functional Collagen \u3cem\u3eVia\u3c/em\u3e Polyvinylpyrrolidone Microneedles [PDF]

, 2015
Collagen makes up a large proportion of the human body, particularly the skin. As the body ages, collagen content decreases, resulting in wrinkled skin and decreased wound healing capabilities.
Inayathullah, Mohammed, Lane, Alfred T., Malkovskiy, Andrey V., Manickam, Sathish, Manoukian, Martin A. C., Marinkovich, M. Peter, Rajadas, Jayakumar, Seifalian, Alexander M., Sun, Wenchao, Tayebi, Lobat   +9 more
core   +1 more source

A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery

Aging Cell, Volume 25, Issue 2, February 2026.
This study introduces a human cellular aging model using placental trophoblasts (hTSC‐STBs) that mimics key aging features like senescence and genomic instability. It aligns with human tissue aging and responds to anti‐aging treatments, offering a scalable platform to screen potential therapies and bridge lab findings to clinical applications ...
Zhen Feng, Cheuk Shuen Li, Haifeng Fu, Wenxin Jiang, Weiyu Zhang, Yingzhang Huang, Yunying Huang, Timothy Theodore Ka Ki Tam, Yang Li, Fang Liu, Liming Lu, Yin Lau Lee, William Shu Biu Yeung, Gordon Dougan, Pentao Liu   +14 more
wiley   +1 more source

0 = ∞ The Nietzschean Concept of Becoming in the Figures of Christ and Zorba the Greek [PDF]

, 2018
In his Twilight of the Idols, Friedrich Nietzsche praises Heraclitus, the Greek pre-Socratic, for his “assertion that being is an empty fiction.” 1 The philosophical notion of being, which seems to refer to fixed entities or ...
Klapes, Peter
core  

Disruption of ATP Synthase Spatiotemporal Organization, Ca2+ Dynamics, and Contractile Function in Senescent Cardiomyocytes

Aging Cell, Volume 25, Issue 2, February 2026.
Enhanced ATP hydrolysis, ΔΨm flickering, and destabilized ATP synthase dimers collectively reduce ATP availability in senescent cardiomyocytes. This energy deficit is associated with disrupted Ca2⁺ dynamics and contractility. ABSTRACT Heart disease is the leading cause of death in the elderly population.
Silke Morris, Nico Marx, Gonzalo Barrientos, Isidora Molina‐Riquelme, Frank Schmelter, Hugo E. Verdejo, Stefan Peischard, Guiscard Seebohm, Verónica Eisner, Karin B. Busch   +9 more
wiley   +1 more source

Overactivation of Cdc42 GTPase Impairs the Cytotoxic Function of NK Cells From Old Individuals Towards Senescent Fibroblasts

Aging Cell, Volume 25, Issue 2, February 2026.
Unrestrained Cdc42 activity causes failure of cytotoxic function of old NK cells. This is associated with disruption of microtubular network and impaired mitochondrial ATP resulting in reduced conjugation and impaired degranulation of lytic vesicles.
Albert Kallon Koroma, Karmveer Singh, Yongfang Wang, Linda Krug, Philipp Haas, Meinhard Wlaschek, Vadim Sakk, Tanja Schuster, Daniel Fürst, Hubert Schrezenmeier, Rashmi Priyadharshini Dheenadayalan, Stephan Stilgenbauer, Lutz Walter, Hartmut Geiger, Karin Scharffetter‐Kochanek, Pallab Maity   +15 more
wiley   +1 more source