Stromal control of oncogenic traits expressed in response to the overexpression of GLI2, a pleiotropic oncogene. [PDF]
, 2009 Hedgehog signaling is often activated in tumors, yet it remains unclear how GLI2, a transcription factor activated by this pathway, acts as an oncogene. We show that GLI2 is a pleiotropic oncogene.
Albertson, DG +6 more
core
Matrix metalloproteinases-2,-3,-7,-9 and-10, but not MMP-11, are differentially expressed in normal, benign tumorigenic and malignant human keratinocyte cell lines [PDF]
, 2000 In order to investigate the correlations between constitutive proteinase expression and the degree of tumorigenicity of cancer cells we have studied a model system of three keratinocyte cell lines.
Bachmeier, B. E. +4 more
core +1 more source
Long‐read sequencing‐based atlas of tissue‐specific expression of DNM1L transcript variants
The FEBS Journal, EarlyView.Targeted long‐read sequencing resolves full‐length DNM1L (Drp1) isoforms and reveals conserved, tissue‐specific expression patterns across human and mouse tissues. Functional assays show that Drp1 isoforms differ in their ability to drive mitochondrial fission, independent of abundance, with specific exons modulating activity.
Feng Yan +19 more
wiley +1 more source
Pain in the penis due to attraction caused by neodymium magnets
Clinical Case Reports, 2023 Key Clinical Message Multiple neodymium magnets can pinch tissue and cause barotrauma. Be careful if the tissue of the penis or foreskin is pinched, as this may cause foreskin necrosis or damage to the urethra.
Yuki Akiyama, Ryo Ichibayashi
doaj +1 more source
International Journal of Cosmetic Science, EarlyView.Application of CHICORY EXTRACT by a consumer has the ability to evoke positive emotional responses in individuals who come into tactile contact with the treated skin. Abstract Objective Measuring the influence of cosmetic ingredients on the microbiota‐skin‐brain axis is a difficult challenge.
Stefan Hettwer +4 more
wiley +1 more source
The Perceptions on Male Circumcision as a Preventive Measure Against HIV Infection and Considerations in Scaling up of the Services: A Qualitative Study Among Police Officers in Dar es Salaam, Tanzania. [PDF]
, 2012 \ud In recent randomized controlled trials, male circumcision has been proven to complement the available biomedical interventions in decreasing HIV transmission from infected women to uninfected men.
B Auvert +47 more
core +2 more sources
HSV-2 Infection of Human Genital Epithelial Cells Upregulates TLR9 Expression Through the SP1/JNK Signaling Pathway [PDF]
, 2020 It is known that herpes simplex virus type 2 (HSV-2) triggers the activation of Toll-like receptor (TLR) 9 signaling pathway and the consequent production of antiviral cytokines in dendritic cells.
Barreto, M +11 more
core +1 more source
Journal for the Scientific Study of Religion, EarlyView.ABSTRACT Building on scholarship that conceptualizes race and religion as co‐constitutive forces within a “race‐religion constellation,” this article explores how this entanglement—profoundly infused and structured by secularity—is lived and negotiated in everyday life.
Deniz Aktaş
wiley +1 more source
Gene expression of tight junctions in foreskin is not affected by HIV pre-exposure prophylaxis
Frontiers in ImmunologyIntroductionTight junctions (TJs) serve as permeability filters between the internal and external cellular environment. A large number of proteins have been identified to be localized at the TJs.
Emily L. Webb +19 more
doaj +1 more source
Periodontology 2000, EarlyView.Abstract Orthodontic therapy applies forces to teeth, causing an inflammatory reaction in the periodontal ligament. This is repaired by remodeling of the periodontium, allowing tooth displacement. Although orthodontic therapy is mostly initiated during childhood and adolescence, the number of adults seeking this treatment is increasing as our society's
Ludovica Parisi +4 more
wiley +1 more source