Clinical heterogeneity mapping and machine learning-based prediction of recurrence in gallstone disease: a retrospective cohort study of 9,939 patients. [PDF]
Zheng X +6 more
europepmc +1 more source
Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang +7 more
wiley +1 more source
How Mixed Are Production-Oriented Planted Forests? A Global Review and Classification Approach. [PDF]
Cagnoni LB +4 more
europepmc +1 more source
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu +9 more
wiley +1 more source
Effects of Zinc Supplementation on Glycemic Control, Insulin Resistance, Inflammation and Oxidative Stress in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. [PDF]
Loaiza-Giraldo JP +15 more
europepmc +1 more source
TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao +8 more
wiley +1 more source
Heterogeneous associations between domain-specific physical activity and sarcopenia risk in diabetic adults: A causal forest analysis. [PDF]
Song D +8 more
europepmc +1 more source
Guided by a Random Forest model, a π–π‐driven ordered stacking strategy deploys functionally distinct substructures to restrict chain segment motion and increase free volume, while preserving the intermolecular interactions that maintain structural integrity.
Zi‐Meng Xu +10 more
wiley +1 more source
Depression prediction and key factors: A comparative analysis of logistic regression and machine learning models. [PDF]
Josten K, Jaganathan V.
europepmc +1 more source

