Advanced Science, EarlyView.Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries +25 more
wiley +1 more source
Can Artificial Tree Cavities Provide Population Support to Cavity-Dependent Non-Flying Mammals? [PDF]
Ecol EvolGoldingay RL, Thomas KJ, Quin DG.
europepmc +1 more source
Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae
Advanced Science, EarlyView.Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch +6 more
wiley +1 more source
Hydrological Conditions Drive Colonial Waterbird Breeding Dynamics in Monsoon-Dependent Wetlands of Southern India. [PDF]
Ecol EvolJacob A, Gopi GV.
europepmc +1 more source
The use of burned forest by breeding birds following the Biscuit Fire in southwest Oregon [PDF]
Fire severity is hypothesized as an important driver of bird responses to wildfire. For those species that typically respond negatively to increasing severity, Accessibility of high-severity burned forest may be dependent on the proximity of unburned or ...
Donaghy Cannon, Michelle M.
core
Advanced Science, EarlyView.An attention‐based multimodal deep learning framework is developed to predict the creep life of Ni‐based superalloys by fusing processing parameters with microstructural micrographs. The model achieves high accuracy (R2 = 0.92), aligns with metallurgical principles by capturing δ‐phase influence, and incorporates uncertainty quantification, offering a ...
Haopeng Lv +10 more
wiley +1 more source
Improving grain yield prediction in Southern US oat germplasm using genomics information and environmental covariates. [PDF]
Plant GenomeAdewale SA +11 more
europepmc +1 more source
Advanced Science, EarlyView.ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao +6 more
wiley +1 more source
A Lightweight Real-Time Vision Framework for Low-Disturbance Veterinary Management and Behavioral Welfare Assessment in Captive Forest Musk Deer. [PDF]
Vet SciGuo D +7 more
europepmc +1 more source
Species-specific variation in nesting and postfledging resource selection for two forest breeding migrant songbirds. [PDF]
PLoS One, 2017 Jenkins JMA, Thompson FR, Faaborg J.
europepmc +1 more source