Results 31 to 40 of about 1,918,026 (260)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

The relationship among stress-wave-based wood stiffness and growth traits revealed by planting density trial with multiple genotypes in Cryptomeria japonica

Journal of Wood Science
Understanding the genetic and environmental factors influencing wood stiffness is essential for improving wood quality in plantation forestry. In this study, we investigated the phenotypic, genetic, and environmental variation in wood stiffness, measured
Eitaro Fukatsu, Yuji Kurahara, Manabu Kurita, Koji Matsunaga   +3 more
doaj   +1 more source

A candidate gene association analysis identifies SNPs potentially involved in drought tolerance in European beech (Fagus sylvatica L.)

Scientific Reports, 2021
Studies of genetic variation underlying traits related to drought tolerance in forest trees are of great importance for understanding their adaptive potential under a climate change scenario.
Laura Cuervo-Alarcon, Matthias Arend, Markus Müller, Christoph Sperisen, Reiner Finkeldey, Konstantin V. Krutovsky   +5 more
doaj   +1 more source

Density and distribution of passerines in a managed coniferous forest: the influence of landscape structure [PDF]

, 2001
This study utilises breeding bird data collected by Patterson et al. 1995 (1991 and 1992) and C.A.McSorley (1998 and 1999), in Kielder Forest, collected using the point count survey methodology.
McSorley, Claire Alice
core  

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

An Arabidopsis zinc finger protein increases abiotic stress tolerance by regulating sodium and potassium homeostasis, reactive oxygen species scavenging and osmotic potential

Frontiers in Plant Science, 2016
Plant zinc finger proteins (ZFPs) comprise a large protein family and they mainly involve in abiotic stress tolerance. Although Arabidopsis RING/FYVE/PHD ZFP (At5g62460; AtRZFP) is found to bind to zinc, whether it is involved in abiotic stress tolerance
Dandan Zang, Hongyan Li, Hongyun Xu, Wenhui Zhang, Yiming Zhang, Xinxin Shi, Yucheng Wang, Yucheng Wang   +7 more
doaj   +1 more source

Breeding, survival, movements and foraging of tawny owls strix aluco in a managed spruce forest: a spatial approach [PDF]

, 2000
In 1996-98,1 studied the spatial ecology of the tawny owl Strix aluco (L.) in Kielder, a managed spruce forest in Northumberland, northern England. I employed radio tracking in an individual-based approach, estimating densities of field voles Microtus ...
Coles, Christopher Frederick
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Evaluation of stem diameter, Pilodyn penetration, and stress-wave velocity of stem in almost 320 clones of the first-generation plus trees of Chamaecyparis obtusa selected from the Kanto breeding region

Journal of Wood Science
Tree breeding programs in Japan have aimed to improve both growth and wood quality traits in Chamaecyparis obtusa. To enhance breeding for wood quality, it is essential to understand the genetic variability of traits related to growth, wood density, and ...
Yusuke Takahashi, Michinari Matsushita, Soichiro Nagano, Tomonori Hirao, Eitaro Fukatsu   +4 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source