Results 91 to 100 of about 99,245 (263)

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

Advanced Science, EarlyView.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu, Qishuai Chen, Yan Ma, Yang Liu, Xianing Dong, Wenjuan Wei, Jianxin Du, Shusheng Qiu, Maojin Tian, Peiqing Zhao   +9 more
wiley   +1 more source

Advancing the understanding of forest conservation dynamics through livelihood and landscape change scenarios: a case study in Chiapas, Mexico. [PDF]

Environ Dev Sustain, 2023
Alfonso-Bécares D, Giampietro M, Corbera E, Serrano-Tovar T.   +3 more
europepmc   +1 more source

TSTScope Unifies Single‐Cell Multi‐Omics to Identify Functional T Cell States Predictive of Immunotherapy Response

Advanced Science, EarlyView.
TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao, Jinyu Cheng, Feng‐ao Wang, Chenxin Yi, Jiajun Chen, Keyue Wang, Lulu Liu, Junwei Liu, Yixue Li   +8 more
wiley   +1 more source

Application of the extended theory of planned behavior in predicting the behavioral intentions of Iranian local communities toward forest conservation. [PDF]

Front Psychol, 2023
Savari M, Khaleghi B.
europepmc   +1 more source

Multi‐Scale Bionic Structure Constructs Biomass Flame‐Retardant Thermal Insulation Foam Material

Advanced Science, EarlyView.
Inspired by mussel adhesion and hierarchical brick‐and‐mortar architectures, a cellulose‐based biomimetic foam is constructed by anchoring bentonite nanosheets onto a polydopamine‐decorated cellulose nanofiber network. The resulting foam combines low thermal conductivity with intrinsic flame retardancy and full biodegradability, presenting a ...
Jianming Liao, Lijun Fan, Yunyuan Dong, Xuyu Bao, Xiaobin Chen, Qifu Zheng, Guanqing Zhang, Shen Wang, Wei Chen, Min Zhang, Shuaiming He   +10 more
wiley   +1 more source

Abundance of Dendroctonus frontalis and D. mexicanus (Coleoptera: Scolytinae) along altitudinal transects in Mexico: Implications of climatic change for forest conservation. [PDF]

PLoS One, 2023
Sáenz-Romero C, Cambrón-Sandoval VH, Hammond W, Méndez-González J, Luna-Soria H, Macías-Sámano JE, Gómez-Romero M, Trejo-Ramírez O, Allen CD, Gómez-Pineda E, Del-Val E.   +10 more
europepmc   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source

Correction to: Conifers and non-native tree species shift trophic niches of generalist arthropod predators in central european beech forests

BMC Ecology and Evolution, 2023
Benjamin Wildermuth, Riko Fardiansah, Dragan Matevski, Jing‑Zhong Lu, Peter Kriegel, Stefan Scheu, Andreas Schuldt   +6 more
doaj   +1 more source

Reconsidering priorities for forest conservation when considering the threats of mining and armed conflict. [PDF]

Ambio, 2022
Williams BA, Grantham HS, Watson JEM, Shapiro AC, Plumptre AJ, Ayebare S, Goldman E, Tulloch AIT.   +7 more
europepmc   +1 more source

F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
ABSTRACT Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer.
Lei Gao, Qinying Han, Yunpeng Wang, Xuemei Li, Bofang Wang, Baohong Gu, Weidong Li, Lin Xiang, Ying Zhang, Hao Chen   +9 more
wiley   +1 more source