Results 201 to 210 of about 4,650,602 (260)

A Unified Hierarchical Multiscale Fusion Framework for Drug–Target Affinity Prediction: From Benchmark Performance to Nanomolar Inhibitor Discovery

Advanced Science, EarlyView.
A multimodal fusion framework integrating sequence, atomic, and fragment representations captures drug–target interactions across multiple scales. The model delivers strong predictive performance and enables efficient virtual screening. Applied to hematopoietic progenitor kinase 1 (HPK1), it identifies structurally diverse inhibitors with nanomolar ...
Shuo Liu, Xiang Zhang, Haixia Feng, Yuquan Li, Xiaoqing Gong, Yong Liang, Xiaojun Yao, Huanxiang Liu   +7 more
wiley   +1 more source

Author Correction: Quantifying mammalian genomic DNA hydroxymethylcytosine content using solid-state nanopores

Scientific Reports
Osama K. Zahid, Boxuan Simen Zhao, Chuan He, Adam R. Hall   +3 more
doaj   +1 more source

Tissue‐Agnostic Cellular Morphometric Biomarkers for Risk‐Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers

Advanced Science, EarlyView.
An interpretable, unsupervised artificial intelligence framework identifies a 13‐cellular morphometric biomarker (CMB) signature from routine H&E whole‐slide images. Validated across 2,602 patients, the fixed signature generalizes across colorectal, gastric, and esophageal tissues without retraining, stratifies prognosis and precancerous lesion risk ...
Pin Wang, Chengfei Jiang, April W. Mao, Qi Sun, Yijun Lu, Jingjing Wei, Jamie L. Inman, Susan E. Celniker, Antoine M. Snijders, David W. Threadgill, Allan Balmain, Bo Hang, Hang Chang, Lei Wang, Jian‐Hua Mao   +14 more
wiley   +1 more source

Low Latency Global Carbon Budget Reveals Late 2024 Carbon Losses and Contrasting Early 2025 Land Sink Recovery Signals

Advanced Science, EarlyView.
Low latency carbon budget estimates for July 2024–June 2025 combine atmospheric CO2 growth rates, fossil emissions, ocean uptake, DGVM land fluxes, and OCO‐2 inversions. The budget shows that late‐2024 land carbon losses dominate the annual anomaly, while early‐2025 recovery differs between bottom‐up models and top‐down inversions, especially in ...
Piyu Ke, Philippe Ciais, Yitong Yao, Stephen Sitch, Wei Li, Xiaomeng Du, Xiaofan Gui, Ben Poulter, Thomas Colligan, Auke M. van der Woude, Joram Hooghiem, Wouter Peters, Zhu Liu, Zhu Deng, Zhe Jin, Xiangjun Tian, Yilong Wang, Junjie Liu, Sudhanshu Pandey, Chris O'Dell, Jiang Bian, John Miller, Xin Lan, Jefferson Goncalves De Souza, Michael O'Sullivan, Pierre Friedlingstein, Julien Alléon, Yi Xi, Daniel S. Goll, Lei Zhu, Guido R. van der Werf, Shilong Piao, Frédéric Chevallier   +32 more
wiley   +1 more source

From Sensing Mechanisms to System Co‐Design: Graphene‐Based Sensors and Readout Circuits

Advanced Science, EarlyView.
This review establishes a unified PS–EQ–RF framework linking graphene sensing mechanisms, native electrical outputs, and output‐specific readout circuits. Voltage‐, current‐, resistance‐, and capacitance‐type sensing systems are systematically classified to guide architecture selection, low‐noise design, system co‐design, and practical integration ...
Jinduo Zhang, Meng Chen, Guanchen Li, Ruifeng Liu, Yingxin Wang, Ziran Zhao   +5 more
wiley   +1 more source

On the dynamics of temperate forests

Bohn, Friedrich J., Universität Osnabrück   +1 more
openaire   +1 more source

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A scalable simulator for forest dynamics

Proceedings of the twentieth annual symposium on Computational geometry, 2004
Models of forest ecosystems are needed to understand how climate and land-use change can impact biodiversity. In this paper we describe an individual-based, spatially-explicit forest simulator with full accounting of both landscape context and the fine-scale processes that influence forest dynamics.
Sathish Govindarajan, Mike Dietze, Pankaj K. Agarwal, James S. Clark   +3 more
openaire   +2 more sources

Forest dynamics in Hawaii

Trends in Ecology & Evolution, 1987
The land surfaces of the Hawaiian islands represent an age sequence from very recent on the island of Hawaii to over 5 million years old on the island of Kauai. Development of indigenous forest on the new basaltic lava flows of Hawaii begins with Metrosideros polymorpha forming mono-dominant canopy stands within 400 years in lowland rain forest ...
openaire   +2 more sources

Predictive Models of Forest Dynamics

Science, 2008
Dynamic global vegetation models (DGVMs) have shown that forest dynamics could dramatically alter the response of the global climate system to increased atmospheric carbon dioxide over the next century. But there is little agreement between different DGVMs, making forest dynamics one of the greatest sources of uncertainty in predicting future climate ...
Drew, Purves, Stephen, Pacala
openaire   +2 more sources

Forest dynamics in the tropics.

2013
This chapter discusses the dynamics of tropical forests. Specifically, the chapter presents the following topics: deforestation; forest land use dynamics; forest dynamics as a process of co-evolution in social and ecological conditions; forest transition pathways; reforestation; and policies that enhance forest conservation and extension.
openaire   +1 more source