Results 241 to 250 of about 719,039 (308)

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

open access: yesAdvanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu   +15 more
wiley   +1 more source

“More” Artificial mRNAs: Beyond the Art of Nature

open access: yesAdvanced Science, EarlyView.
Inspired by nature yet transcending it, synthetic mRNA is being redesigned beyond the canonical architecture. This review highlights emerging forms—circular, branched, and self‐amplifying mRNAs—that expand stability, persistence, and functional control, illustrating how artificial mRNA is evolving into a new medium for programmable biological ...
Yuanzhe Cui   +3 more
wiley   +1 more source

Remote sensing analysis of forest fire impacts on ecosystem productivity, greenhouse gas emissions, and fire risk in Pakistan. [PDF]

open access: yesCarbon Balance Manag
Shahzad F   +7 more
europepmc   +1 more source

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