Results 51 to 60 of about 4,650,602 (260)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Wall-to-Wall Tree Type Mapping from Countrywide Airborne Remote Sensing Surveys

Remote Sensing, 2017
Although wall-to-wall, accurate, and up-to-date forest composition maps at the stand level are a fundamental input for many applications, ranging from global environmental issues to local forest management planning, countrywide mapping approaches on the ...
Lars T. Waser, Christian Ginzler, Nataliia Rehush   +2 more
doaj   +1 more source

Deep Dynamic Boosted Forest

, 2018
Random forest is widely exploited as an ensemble learning method. In many practical applications, however, there is still a significant challenge to learn from imbalanced data. To alleviate this limitation, we propose a deep dynamic boosted forest (DDBF), a novel ensemble algorithm that incorporates the notion of hard example mining into random forest.
Haixin Wang 0003, Xingzhang Ren, Jinan Sun, Wei Ye 0004, Long Chen, Muzhi Yu, Shikun Zhang   +6 more
openaire   +3 more sources

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Tree‐Ring Anatomy Improves the Reliability of Temperature Reconstructions Using Relict Wood

Geophysical Research Letters
Tree rings are crucial for reconstructing past climates, with maximum latewood density (MXD) as a key metric. However, wood integrity is critical for accurate MXD‐based reconstructions, raising concerns when using potentially degraded relict wood ...
Stefan Klesse, Jesper Björklund, Marina V. Fonti, Daniel Nievergelt, Georg von Arx, Rashit M. Hantemirov, Vladimir V. Kukarskih, Lisbeth Garbrecht Thygesen, Nanna Bjerregaard Pedersen, Patrick Fonti   +9 more
doaj   +1 more source

Plasticity of Fine-Root Traits Under Long-Term Irrigation of a Water-Limited Scots Pine Forest

Frontiers in Plant Science, 2019
Trait-based approaches are increasingly used to investigate plant strategies for resource acquisition, growth, or competition between individual organisms or across species. However, the characterization of responses to environmental stimuli by fine-root
Ivano Brunner, Claude Herzog, Lucía Galiano, Lucía Galiano, Lucía Galiano, Arthur Gessler   +5 more
doaj   +1 more source

Phenological characterization of Fagus sylvatica L. in Mediterranean populations of the Spanish Central Range with Landsat OLI/ETM+ and Sentinel-2A/B

Revista de Teledetección, 2020
The Spanish Central Range hosts some of the southernmost populations of Fagus sylvatica L. (European beech). Recent cartography indicates that these populations are expanding, going up-streams and gaining ground to oak forests of Quercus pyrenaica Willd.,
C. Gómez, P. Alejandro, F. Montes
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Cambial Activity of Moringa peregrina (Forssk.) Fiori in Arid Environments

Frontiers in Plant Science, 2021
Moringa peregrina (Forssk.) Fiori, one of 13 species of the Moringaceae family widely distributed throughout the dry tropics, has the potential to become one of the most economically important medicinal plants in Egypt. However, despite its tolerance for
Holger Gärtner, Emad Farahat
doaj   +1 more source