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Results 181 to 190 of about 120,987 (294)

Inosine‐Triphosphate‐Pyrophosphatase Activity as a Potential Predictor of Methotrexate Remission in Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients do not respond to it. Low inosine triphosphate pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated the role and underlying mechanisms of ITPA in vitro. Methods ITPA enzymatic activity
Sofia Sindici Forgiarini +19 more
wiley +1 more source

Habitat-driven variation in gut microbiome composition and function of the pygmy grasshopper (Tetrix japonica) across diverse ecosystems in China. [PDF]

BMC Genomics
Li Y, Liu L, Long M, Guan D, Deng W.
europepmc +1 more source

Unveiling Endotypes in Systemic Lupus Erythematosus Through Multiomic Analysis: Insights Into Cardiovascular and Renal Complications

Arthritis &Rheumatology, EarlyView.
Objective Systemic lupus erythematosus (SLE) shows clinical and molecular heterogeneity, and cardiovascular (CV) complications and lupus nephritis (LN) remain leading causes of morbidity and mortality. This study investigated whether omic profiling can reveal molecular endotypes linked to these outcomes.
Tomás Cerdó +84 more
wiley +1 more source

Landscape Genomics and Evolutionary History of <i>Megamelus scutellaris</i>, a Biocontrol Agent of the Invasive Water Hyacinth (<i>Pontederia crassipes</i>). [PDF]

Evol Appl
Salinas NA +5 more
europepmc +1 more source

Clock genes regulate Ca2+ signaling and mitochondrial bioenergetics to inhibit Sjogren's disease

Arthritis &Rheumatology, Accepted Article.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjogren's disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA seq, and mitochondrial activity were used to investigate the effects of ...
Viktor R. Drel +12 more
wiley +1 more source

Immune Cell-Mediated Retinoblastoma Development: Genetic and Molecular Mechanisms. [PDF]

Int J Genomics
Hu X +11 more
europepmc +1 more source

Higher complement C4 gene copy number constitutes a shared genetic risk factor for giant cell arteritis and IgA vasculitis

Arthritis &Rheumatology, Accepted Article.
Objective Low copy number (CN) of complement C4 isoforms and high CN of retroviral HERV‐K elements are known risk factors for many immune‐mediated inflammatory diseases (IMIDs), often showing sex‐biased effects. Here, we assessed whether CN variation within the C4 gene contributes to giant cell arteritis (GCA) and IgA vasculitis (IgAV), two complex ...
Laura Martínez‐Gutiérrez +296 more
wiley +1 more source

Glandular Cells of Forest Musk Deer Autonomously Synthesize Sex Steroid Hormones. [PDF]

Biology (Basel)
An X +15 more
europepmc +1 more source

Production of bacterial cellulose by Acetobacter okinawensis AC2 and its application as a bioadsorbent for azo dye removal

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract Bacterial cellulose (BC) is a naturally occurring polysaccharide that has attracted considerable interest in various fields, including biological and biomedical applications, due to its biodegradability, biocompatibility, high degree of crystallinity, and outstanding physicochemical characteristics. It is widely used in several industries such
Mehmet Akif Omeroglu, Neslihan Keles, Mesut Taskin +2 more
wiley +1 more source

Efficacy and safety of empagliflozin for treating neutropenia and neutrophil dysfunction in paediatric patients with glycogen storage disease type Ib: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Glycogen storage disease type Ib (GSD‐Ib) is a rare genetic disorder causing neutropenia and neutrophil dysfunction in children. G‐CSF has been the primary treatment, but emerging data support the potential of empagliflozin, an SGLT2 inhibitor, as a promising investigational option.
Elizabeth Iwasyk +5 more
wiley +1 more source

15. life on land
genomics
trees

genome, plant
adaptation
13. climate action

2. zero hunger
conifers
forestry