Results 211 to 220 of about 249,780 (278)

Multi‐regional Organoid Biobank Reveals FAK‐ACSL1‐Driven Doxorubicin‐Resistance and Predictive Biomarkers in Breast Cancer

Advanced Science, EarlyView.
This study established a high‐quality organoid biobank derived from 68 tumor sites across 50 Chinese patients, elucidated the drug sensitivity‐based molecular subtyping in breast cancer, and revealed a novel mechanism of drug resistance mediated by the FAK‐ACSL1 pathway.
Hao Xu, Zhijun Qin, Jiapeng Yang, Baoyuan Zhang, Manqing Cao, Peng Wang, Zaiqi Wang, Jinghui Cheng, Lei Wang, Hong Liu, Hui Yang   +10 more
wiley   +1 more source

A data-driven approach for high-accuracy tool wear prediction in machining Hastelloy C276. [PDF]

Sci Rep
Abdullah M, Rao ACU, Ramachandran T, Biswal S, Chaudhary SP, Singh R, Mishra A, Mann VS, Bhowmik A, Abate L.   +9 more
europepmc   +1 more source

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

Carcinogenicity prediction via multi-task learning of cross-organ representations with attention mechanisms. [PDF]

Brief Bioinform
Song Y, Choi H, Yoo S.
europepmc   +1 more source

Human‐Guided Bayesian Optimization Enables High‐Throughput Laser Annealing of Mesoporous SiOx Anodes for Lithium‐Ion Batteries

Advanced Science, EarlyView.
An empirical‐aided active learning framework is developed to optimize high‐throughput laser‐induced photothermal annealing of silicon suboxide anodes. By integrating probabilistic machine learning with empirical domain knowledge, this approach achieves optimal electrochemical performance using limited experiments.
Chaeyoung Park, Yeongje Lee, Sunho Jeong, Eungkyu Lee   +3 more
wiley   +1 more source

Hospital efficiency assessment: a systematic review of DEA and hybrid DEA-machine learning approaches. [PDF]

Front Med Technol
Alkan N, Koluk UK, Alkan BB, Sinan A.
europepmc   +1 more source

A Sustainable Bio‐Based Epoxy Thermoset as a High‐Performance Alternative to BPA‐Based Resins

Advanced Science, EarlyView.
A rigid–flexible bio‐based epoxy network integrates soybean oil, lignin, and maleic anhydride to overcome the strength–toughness–sustainability trade‐off of conventional BPA epoxy. The thermoset delivers excellent performance as both a structural adhesive and a matrix for glass‐fabric composites, while enabling pH‐responsive degradation, environmental ...
Jiyun Qi, Xinyi Hui, Xipeng Zhang, Jia‐Long Wen, Tong‐Qi Yuan   +4 more
wiley   +1 more source

Morphological and molecular evidence reveal two new species of <i>Sutorius</i> (Boletaceae, Basidiomycota) from Guizhou Province, China. [PDF]

MycoKeys
Xu XH, Mo X, Chen AM, Li YD, Pei Y, Li JW, Wen TC, Karunarathna SC, Tarafder E, Zhang WP.   +9 more
europepmc   +1 more source

A Universal Protein Ladder for Standardization of Diverse FRET Assays

Advanced Science, EarlyView.
Translating FRET measurements from in vitro to intracellular environments requires universal benchmarks. We present a modular protein ladder using TPR motifs to harmonize data across diverse platforms. This predictable calibration curve bridges single molecule FRET measurements, with cell based measurements including FLIM‐FRET.
Evelyn R. Smith, Katie L. Gelder, Lewis Hunter‐Craig, Daniel A. Bose, Timothy D. Craggs, Alison E. Twelvetrees   +5 more
wiley   +1 more source

Effects of caffeine and tannin treatments on biodegradation resistance and fire retardancy of oriented strand board (OSB) panels. [PDF]

Mater Struct
López-Gómez YM, Salomé-Simon FA, Barbero-López A, Cloutier A, Haapala A.   +4 more
europepmc   +1 more source