Results 31 to 40 of about 30,952 (258)

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier, Mark Zobeck, Adam J. Esbenshade, Christopher C. Dvorak, Lillian Sung, David Freyer, Sarah Alexander, Etan Orgel, Nicole J. Ullrich, Zach Prudowsky, Brian Fisher, Caitlin W. Elgarten   +11 more
wiley   +1 more source

INFLUÊNCIA DA TOPOGRAFIA E DA ABERTURA DO DOSSEL NA ESTRUTURA DO COMPONENTE HERBÁCEO-ARBUSTIVO EM DOIS FRAGMENTOS FLORESTAIS NA PLANÍCIE DE INUNDAÇÃO DO ALTO RIO PARANÁ

Ciência Florestal, 2018
Secondary forest area enlarged significantly in the recent years. Due to the importance that this kind of forest has taken regarding plans for restoration and conservation, a wider understanding of its organization and functioning, considering the ...
Marcos Paulo da Cruz, João Batista Campos, José Marcelo Domingues Torezan   +2 more
doaj   +1 more source

Functional Traits and Local Environmental Conditions Determine Tropical Rain Forest Types at Microscale Level in Southern Ecuador

Diversity, 2023
The main objective of this study was to determine the heterogeneity of tropical mountain rain forests along a micro-altitudinal gradient scale, integrating species functional traits in the separation of communities.
Omar Cabrera, Pablo Ramón, Bernd Stimm, Sven Gunter, Reinhard Mosandl   +4 more
doaj   +1 more source

Occurrence of Extramedullary Relapses in Pediatric Acute Lymphoblastic Leukemia After Treatment With Blinatumomab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We report a retrospective single‐center analysis of pediatric patients with relapsed or refractory B‐cell precursor acute lymphoblastic leukemia focusing on relapses outside of the typical locations, bone marrow, central nervous system, or testes.
Johanna Kunz, Martin Ebinger, Michaela Döring, Markus Mezger, Ursula Holzer, Rupert Handgretinger, Peter Lang, Manon Queudeville   +7 more
wiley   +1 more source

Canopy openings in the Trans-Mexican Neovolcanic Belt: Characteristics, distribution, and conservation relevance in a biosphere reserve

Trees, Forests and People
Canopy openings are key drivers of forest dynamics, influencing tree regeneration, species composition, and ecosystem resilience. However, their structural characteristics remain poorly quantified in Mexican forests, particularly in the Monarch Butterfly
Altagracia Guerrero-Marmolejo, Miguel Martínez Ramos, M. Isabel Ramírez, Marco Tulio Oropeza-Sánchez, Miguel Ángel Salinas-Melgoza, Diego R. Pérez-Salicrup   +5 more
doaj   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Assessment of camera focal length influence on canopy reconstruction quality

ISPRS Open Journal of Photogrammetry and Remote Sensing, 2022
Unoccupied aerial vehicles (UAV) with RGB-cameras are affordable and versatile devices for the generation of a series of remote sensing products that can be used for forest inventory tasks, such as creating high-resolution orthomosaics and canopy height ...
Martin Denter, Julian Frey, Teja Kattenborn, Holger Weinacker, Thomas Seifert, Barbara Koch   +5 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source