Results 271 to 280 of about 1,408,150 (349)
Advanced Science, EarlyView.BiSCALE: A pathology‐driven deep learning framework for multi‐scale gene expression prediction from whole‐slide images. It accurately infers bulk and near‐cellular spot‐level expression, links predictions to clinical phenotypes, identifies disease‐associated niches, and enables applications in risk stratification and cell‐identity annotation, providing
Hailong Zheng +8 more
wiley +1 more source
Alkaloid Profile Characterisation and Bioactivity Evaluation of Bolivian <i>Hippeastrum</i> Species (Amaryllidaceae) as Cholinesterase Inhibitors. [PDF]
Life (Basel)Rodríguez-Escobar ML +7 more
europepmc +1 more source
Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis
Advanced Science, EarlyView.This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu +15 more
wiley +1 more source
When the Evidence Points to the Non-Invasive Nature of an Allegedly Invasive Alien Species: The Case of the Aoudad in Mainland Spain. [PDF]
Animals (Basel)Cassinello J +5 more
europepmc +1 more source
Southern pine beetle outbreaks associated with climate change in Honduras [PDF]
, 2009 Billings, Ronald F. +2 more
core
Advanced Science, EarlyView.This study presents a hierarchically channeled graphitized nanoarchitecture (HPGC‐Z67) as a novel nano‐diagnostic platform. It enables sensitive and efficient N‐glycan extraction from plasma, significantly reducing processing time and cost. The platform identifies pivotal N‐glycans to accurately differentiate between infectious and non‐infectious ...
Yiwen Lin +5 more
wiley +1 more source
Diversity Hotspots and Vulnerability of Pine Species in the Sierra Madre Occidental, Western Mexico. [PDF]
Ecol EvolRuacho-González L +5 more
europepmc +1 more source
Advanced Science, EarlyView.PA accumulates after hypoxic‐ischemic injury and stabilizes the E3 ligase TRIM59 in OPCs. Stabilized TRIM59 enhances ubiquitination and degradation of Olig2, blocking differentiation and causing hypomyelination in PWMI. Modulating PA synthesis restores Olig2 levels, improves myelination, and ameliorates behavioral deficits, defining a metabolically ...
Xinyu Li +8 more
wiley +1 more source